Results 31 to 40 of about 166,355 (310)
Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy [PDF]
, 2009 Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer.
B Stordal +7 more
core +2 more sources
Metabolic vulnerability of cisplatin‐resistant cancers [PDF]
The EMBO Journal, 2018 Cisplatin is the most widely used chemotherapeutic agent, and resistance of neoplastic cells against this cytoxicant poses a major problem in clinical oncology. Here, we explored potential metabolic vulnerabilities of cisplatin-resistant non-small human cell lung cancer and ovarian cancer cell lines.
Florine Obrist +11 more
openaire +2 more sources
Literature Review: Mekanisme Resistensi Kemoterapi Berbasis Platinum
Jurnal Kesehatan, 2020 Cisplatin is a type of platinum-based chemotherapy that is often used in the spectrum of solid neoplasms, including the ovaries, testicles, urinary vesicles, colorectal, lungs, and head-neck.
Amelia Rizky Khalidah
doaj +1 more source
Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1
iScience, 2023 Summary: Cisplatin resistance remains a major obstacle limiting the effectiveness of chemotherapy in cervical cancer. However, the underlying mechanism of cisplatin resistance is still unclear.
Xiangyu Tan +9 more
doaj +1 more source
Nature Communications, 2023 Cisplatin resistance along with chemotherapy-induced neuropathic pain is an important cause of treatment failure for many cancer types and represents an unmet clinical need.
Se Jin Oh +15 more
doaj +1 more source
Cisplatin liposome and 6-amino nicotinamide combination to overcome drug resistance in ovarian cancer cells [PDF]
, 2018 Ovarian cancer is an aggressive and lethal cancer usually treated by cytoreductive surgery followed by chemotherapy. Unfortunately, after an initial response, many patients relapse owing mainly to the development of resistance against the standard ...
Catanzaro, Daniela +7 more
core +1 more source
Thoracic Cancer, 2021 Background: Acquired resistance of chemotherapy, especially cisplatin, is a major challenge in lung cancer treatment. We conducted this study to examine whether a cyclin D kinase 4/6 (CDK4/6) inhibitor, PD 0332991, could reverse cisplatin resistance in ...
Minghui Liu +8 more
doaj +1 more source
Pulling a MAST1 on Cisplatin Resistance [PDF]
Cancer Cell, 2018 In this issue of Cancer Cell, Jin and colleagues use a kinome-wide screen to identify MAST1 as a cause of cisplatin resistance. They demonstrate that this kinase is a novel activator of MEK1 and the MAPK cascade and that it can harness pathway output to block cisplatin-induced cell death.
Ankita B, Jaykumar +2 more
openaire +2 more sources
Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin [PDF]
, 2018 Cisplatin and derivatives are commonly used as chemotherapeutic agents. Although the cytotoxic action of cisplatin on cancer cells is very efficient, clinical oncologists need to deal with two major difficulties, namely the onset of resistance to the ...
Boxem, Mike +12 more
core +1 more source
RAB8 Enhances TMEM205-Mediated Cisplatin Resistance [PDF]
Pharmaceutical Research, 2011 To determine whether the small endosomal recycling GTPase, RAB8, plays a role in TMEM205-associated resistance to the chemotherapeutic drug cisplatin.Antibodies were used as markers for both genes; confocal microscopy was used to visualize their localization in cisplatin-resistant cells.
Ding-Wu, Shen, Michael M, Gottesman
openaire +2 more sources