Results 41 to 50 of about 149 (146)

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Non‐Invasive Tumor Budding Evaluation and Correlation with Treatment Response in Bladder Cancer: A Multi‐Center Cohort Study

Advanced Science, EarlyView.
This study introduces a deep learning model that predicts tumor budding (TB) status in bladder cancer through the analysis of CT images. The model effectively identifies patients with high TB status, correlating with poorer prognosis and reduced responsiveness to neoadjuvant chemoimmunotherapy. This tool offers significant potential to inform prognosis
Xiaoyang Li, Chen Zou, Chunhui Wang, Cheng Chang, Yi Lin, Shuai Liang, Haoran Zheng, Libo Liu, Kai Deng, Lin Zhang, Bohao Liu, Mingchao Gao, Peicong Cai, Jianwen Lao, Longhao Xu, Daqin Wu, Xiao Zhao, Xiao Wu, Xinyuan Li, Yun Luo, Wenlong Zhong, Tianxin Lin   +21 more
wiley   +1 more source

Neurotoxicity of cisplatin and taxol

International Journal of Gynecological Cancer, 1995
Since the discovery of the activity of cisplatin in ovarian cancer approximately 15 years ago, there has been little progress in improving survival for patients with this disease. Thus there has been great enthusiasm in the gynecologic oncology community over the results of GOG111, the Gynecologic Oncology Group (GOG) study randomizing suboptimally ...
openaire   +3 more sources

The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening

Advanced Science, EarlyView.
A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie, Qingyang Yang, Yanan Zhang, Ke Zheng, Hongya Geng, Yaojiong Wu   +5 more
wiley   +1 more source

DeepCCDS: Interpretable Deep Learning Framework for Predicting Cancer Cell Drug Sensitivity through Characterizing Cancer Driver Signals

Advanced Science, EarlyView.
DeepCCDS leverages prior knowledge and self‐supervised learning to model cancer driver signals for drug sensitivity prediction. It captures complex regulatory patterns enabling more biologically informed representations. The framework outperforms existing methods across datasets, offering improved accuracy and interpretability.
Jiashuo Wu, Jiyin Lai, Xilong Zhao, Ziyi Wang, Yongbao Zhang, Liqiang Wang, Yinchun Su, Yalan He, Siyuan Li, Ying Jiang, Junwei Han   +10 more
wiley   +1 more source

Label‐Free 3D Photoacoustic Imaging of Tumor Organoids for Volumetric Drug Screening

Advanced Science, EarlyView.
A label‐free organoid photoacoustic imaging (LFOPI) system is developed for precise volumetric drug screening evaluation. As a proof of concept, LFOPI's performance in chemotherapy and immunotherapy drug screening assays are further evaluated. The LFOPI offers unique non‐invasive, label‐free capabilities for tumor organoids, and contributes to the ...
Xiaofei Luo, Maike Chen, Han Shan, Xize Yu, Qibo Lin, Qian Tao, Xiongwei Wei, Changling Lv, Ziyan Chen, Fan Zhuo, Xi Zhu, Jiaxing He, Zhaoxi Li, Chunlong Fei, Jing Xu, Juan Su, Zeyu Chen, Shuang Zhao, Xiang Chen   +18 more
wiley   +1 more source

PRMT1‐Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu, Wentao Zhang, Weiwei Liu, Zhao Ding, Ruijing Zhang, Yuefeng Han, Zihao Niu, Mengdie Zhang, Hui Li, Dapeng Li, Zixi Wang, Jie Peng, Yu Wu, Yanxun Han, Zihui Xie, Jing Wu, Liang Qin, Zhongdong Hu, Xu Chen, Yunlong Hu, Yehai Liu, Shiyin Ma, Xiaojun Zha   +22 more
wiley   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source