Results 81 to 90 of about 149 (146)

Graphene Oxide‐Based Gene Modulation in Preferential Elimination of Lung Cancer Cells in a 3D Tumor Microenvironment Model

Advanced NanoBiomed Research, EarlyView.
Chemically modified graphene oxide nanocarriers provide a targeted lung cancer gene therapy platform. In a 3D tumor microenvironment model, these nanocarriers deliver therapeutic genes, regulate immune markers, and induce apoptosis in cancer cells. Combined gene delivery enhances cancer cell elimination, demonstrating the potential of this approach for
Francesca Grilli, Sadman Sakib, Fabio Variola, Shan Zou   +3 more
wiley   +1 more source

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

Quantitative Analysis of Fluorescent Sensor Arrays

Analysis &Sensing, Accepted Article.
Fluorescent sensor arrays address the limitations of a single sensor by leveraging multiple sensing elements to generate unique response patterns for each of the analyte of interest. This approach has emerged as a powerful tool for identifying and analysing intricate chemical and biological environments using various multivariate analytical tools such ...
Karandeep Grover, Muhammad Tahir Waseem, Haobo Guo, Elizabeth New   +3 more
wiley   +1 more source

Investigation of antibacterial and anticancer activities of biosynthesized metal‐doped and undoped zinc oxide nanoparticles

Biotechnology and Applied Biochemistry, EarlyView.
Abstract Over the past 10 years, nanotechnology has emerged as a very promising technique for a wide range of biomedical applications. Green synthesized metal and metal oxide nanoparticles (NPs) are cheap, easy to produce in large quantities, and safe for the environment.
Kaan Şendal, Mahmure Üstün Özgür, Ebru Ortadoğulu Sucu, Melike Başak Findik, Ömer Erdoğan, Erman Oryaşin, Özge Çevik   +6 more
wiley   +1 more source

Organ toxicities associated with diet‐induced obesity in rats: Investigation of changes in activities selected enzymes

Biotechnology and Applied Biochemistry, EarlyView.
Abstract Obesity stands out as one of the most significant health problems in the modern world. The prevalence of high‐calorie diets (HCDs) globally exacerbates this condition. Throughout history, plants and plant‐derived food products have been utilized for medicinal purposes, demonstrating their efficacy in the treatment and prevention of various ...
Bedia Bati
wiley   +1 more source

The Stem Cell Transcription Factor OCT4 Silences Target DNA Methyltransferase 1 to Strengthen DNA Damage Response in Cisplatin‐Treated Gastric Cancer Cells

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT OCT4 plays a crucial role in the DNA damage response(DDR) mechanism, whereas cisplatin (CDDP) acts as an anti‐tumor agent by inducing DDR. This study aimed to investigate the role of OCT4 in regulating DNA methyltransferase 1 (DNMT1) in CDDP‐treated gastric cancer (GC).
Zhengzheng Yan, Xiaoqian Bu, Haixia Chen, Chongren Ren, Ji Li, Yongjie Wu, Jun Xing   +6 more
wiley   +1 more source

Effect of hydration schedules on dose‐limiting toxicity in patients with head and neck squamous cell carcinoma treated with cisplatin

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to determine if head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin chemoradiotherapy and short hydration (SH) experience less dose‐limiting toxicity (DLT) and receive more cisplatin than those with medium hydration (MH) or long hydration (LH).
Anouk W. M. A. Schaeffers, Cassimy B. van Neerven, Dorieke van Balen, Mirjam Crul, Marije Slingerland, Saskia A. C. Luelmo, Jan Paul de Boer, Jens Voortman, Arjan D. van Zuilen, Remco de Bree, Lot A. Devriese   +10 more
wiley   +1 more source

Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects

BMEMat, EarlyView.
This review summarizes the latest progress in nanomaterials for X‐ray‐triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. Abstract X‐rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical ...
Yuanchun Chen, Shijie Shangguan, Zhongyu Lin, Xuemei Zeng, Siew Yin Chan, Xian Qin, Shuangqian Yan   +6 more
wiley   +1 more source

X‐ray controlled release strategy in cancer therapy

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of X‐ray stimulated release systems in cancer therapy, focusing on the X‐ray responsive functional groups and materials as well as discussing the advantages and current challenges of X‐ray controlled release systems in cancer therapy.
Yiling Ruan, Hongxiang Huang, Huihui Liu, Jinglang Gong, Changjun Li, Xiaolian Sun   +5 more
wiley   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source