Results 1 to 10 of about 164,596 (212)

Autophagy and extracellular vesicles mediate cisplatin resistance in oral squamous cell carcinoma with LC3B-II as a potential non-invasive biomarker

Scientific Reports
Drug resistance remains a critical challenge in cancer chemotherapy, particularly in oral squamous cell carcinoma (OSCC). Recent findings have highlighted the significant roles that autophagy and extracellular vesicles (EVs) play in contributing to ...
Kar-Yan Su, Xin-Hui Khoo, Ian C. Paterson, Bey-Hing Goh, Wai-Leng Lee   +4 more
doaj   +1 more source

Microchamber Cultures of Bladder Cancer: A Platform for Characterizing Drug Responsiveness and Resistance in PDX and Primary Cancer Cells. [PDF]

, 2017
Precision cancer medicine seeks to target the underlying genetic alterations of cancer; however, it has been challenging to use genetic profiles of individual patients in identifying the most appropriate anti-cancer drugs. This spurred the development of
Dall'Era, Marc A, de Vere White, Ralph W, Gheibi, Pantea, Ma, Ai-Hong, Pan, Chong-Xian, Revzin, Alexander, Son, Kyung Jin, Vu, Tam, Yap, Stanley Alexander, Zeng, Shuxiong   +9 more
core   +2 more sources

Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer

Frontiers in Pharmacology, 2017
Cisplatin (DDP) is currently one of the most commonly used chemotherapeutic drugs for treating ovarian and lung cancer. However, resistance to cisplatin is common and it often leads to therapy failure.
Wujian Zheng, Qi Feng, Jiao Liu, Yanke Guo, Lvfen Gao, Ruiman Li, Meng Xu, Guizhen Yan, Zhinan Yin, Shuai Zhang, Shuangping Liu, Changliang Shan   +11 more
doaj   +1 more source

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. [PDF]

, 2015
MCM8-9 complex is required for homologous recombination (HR)-mediated repair of double-strand breaks (DSBs). Here we report that MCM8-9 is required for DNA resection by MRN (MRE11-RAD50-NBS1) at DSBs to generate ssDNA.
Dutta, Anindya, Handa, Naofumi, Im, Jun-Sub, Kowalczykowski, Stephen C, Lee, Kyung Yong, Park, Jonghoon, Shibata, Etsuko   +6 more
core   +1 more source

In Vitro Chemosensitivity Using the Histoculture Drug Response Assay in Human Epithelial Ovarian Cancer [PDF]

, 2012
The choice of chemotherapeutic drugs to treat patients with epithelial ovarian cancer has not depended on individual patient characteristics. We have investigated the correlation between in vitro chemosensitivity, as determined by the histoculture drug ...
Kim, Dae-Yeon, Kim, Jong-Hyeok, Kim, Moon-Bo, Kim, Yong-Man, Kim, Young-Tak, Lee, Shin-Wha, Nam, Joo-Hyun   +6 more
core   +1 more source

Resensitization of cisplatin resistance ovarian cancer cells to cisplatin through pretreatment with low‐dose fraction radiation

Cancer Medicine, 2019
Objective Cisplatin is the first‐line chemotherapy for ovarian cancer. However, cisplatin resistance is severely affecting the treatment efficacy. FOXO3a has been reported to be involved in reversing chemotherapy resistance.
Lili Zhao, Shihai Liu, Donghai Liang, Tao Jiang, Xiaoyan Yan, Shengnan Zhao, Yuanwei Liu, Wei Zhao, Hongsheng Yu   +8 more
doaj   +1 more source

Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway. [PDF]

, 2015
Tumor recurrence remains an obstacle after liver surgery, especially in living donor liver transplantation (LDLT) for patients with hepatocellular carcinoma (HCC).
Geng, Wei, Li, Chang-Xian, Ling, Chang-Chun, Liu, Xiao-Bing, Lo, Chung-Mau, Ma, Yuen-Yuen, Man, Kwan, Ng, Kevin TP, Qi, Xiang, Zhai, Yuan   +9 more
core   +1 more source

Curcumin reverses cisplatin resistance in cisplatin-resistant lung caner cells by inhibiting FA/BRCA pathway

Tumor Biology, 2014
Cisplatin (DDP) is the most widely used chemotherapy agent for treatment of malignancies including lung cancer. However, the effectiveness of DDP is often weakened by acquired resistance of tumor cells. DDP kills cancer cells primarily by creating intrastrand and interstrand DNA cross-links, which block DNA replication.
Ping, Chen, Jian, Li, He-Guo, Jiang, Ting, Lan, Yong-Chang, Chen   +4 more
openaire   +2 more sources

Cucurbit[n]uril binding of platinum anticancer complexes [PDF]

, 2005
The encapsulation of cisplatin by cucurbit[7]uril (Q[7]) and multinuclear platinum complexes linked via a 4,4′-dipyrazolylmethane (dpzm) ligand by Q[7] and cucurbit[8]uril (Q[8]) has been studied by NMR spectroscopy and molecular modelling.
Anthony I. Day, Baird, Bancroft, Battle, Blanch, Blasi, Boulikas, Calvert, Clarke, Colella, Collins, Damian P. Buck, Day, Farrell, Farrell, Farrell, Farrell, Farrell, Fu, Hartmann, Hegmans, J. Grant Collins, Jansen, Jeon, Jeon, Jodrell, Kelland, Kelland, Kim, Kim, Lorenzo, Manzotti, Marquez, Mock, Mock, Nial J. Wheate, Ong, Pavankumar, Perego, Perego, Perego, Piccart, Pratesi, Riccardi, Roberts, Roberts, Scagilotti, Servidei, Sessa, Sharp, Villa, Wheate, Wheate, Wheate, Wheate, Wheate, Wheate, Wong, Zhang   +58 more
core   +1 more source

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. [PDF]

, 2019
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. Tumor relapse following chemotherapy treatment has long been a significant challenge towards completely curing cancer.
de Vere White, Ralph, Ghosh, Paramita M, He, Wei, Hum, Nicholas R, Loots, Gabriela G, Martin, Kelly A, Pan, Chong-Xian, Sebastian, Aimy, Siddiqui, Salma   +8 more
core   +2 more sources