Results 21 to 30 of about 18,692 (215)
Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023 Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki +4 more
wiley +1 more source
Hematology, Transfusion and Cell Therapy, 2023 O Sangue de Cordão Umbilical e Placentário (SCUP) tem se destacado como uma valiosa fonte de citocinas e Fatores de Crescimento (FCs). Neste estudo, o objetivo foi investigar a presença de citocinas e FCs no sobrenadante de concentrado de hemácias obtido
MA Risso, E Deffune, ACM Luzo
doaj +1 more source
Veterinary Dermatology, Volume 33, Issue 4, Page 329-e77, August 2022., 2022 Background– Cannabidiol (CBD) and cannabidiolic acid (CBDA) are reported to have antinociceptive, immunomodulatory and anti‐inflammatory actions. Objectives – To determine if CBD/CBDA is an effective therapy for canine atopic dermatitis (cAD). Conclusions and clinical relevance – Cannabidiol/CBDA as an adjunct therapy decreased pruritus, and not skin ...
Melissa Loewinger +4 more
wiley +1 more source
Altered plasma cytokines in dogs with atopic dermatitis
Veterinary Dermatology, Volume 33, Issue 2, Page 131-e38, April 2022., 2022 Background – Canine (Canis lupus familiaris) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, Regulatory T (Treg) cells, eosinophils, mast cells and other immune components.
Hamutal Mazrier +3 more
wiley +1 more source
Onset and duration of action of lokivetmab in a canine model of IL‐31 induced pruritus
Veterinary Dermatology, Volume 32, Issue 6, Page 681-e182, December 2021., 2021 Onset of antipruritic action of lokivetmab in dogs. Laboratory‐bred beagle dogs were dosed subcutaneously with either placebo or lokivetmab at 2.0 mg/kg on Day (D) 0. Approximately 2.5 h post‐dosing, pruritus was induced using canine interleukin (IL)‐31. Animals were observed for pruritic behaviours for a total of 2 h (3–5 h post‐treatment with placebo
Timothy J. Fleck +6 more
wiley +1 more source
Citocinas e quimiocinas no transplante renal [PDF]
Jornal Brasileiro de Nefrologia, 2009 O transplante renal e a melhor modalidade de terapia renal substutiva ate o momento. Infelizmente, a sobrevida do enxerto e interrompida pelos episodios de rejeicao aguda ou mesmo de fibrose intersticial/atrofia tubular. A dosagem de quimiocinas e citocinas urinarias como ferramenta alternativa para o diagnostico dessas complicacoes tem sido relatada ...
Pereira, André Barreto +4 more
openaire +3 more sources
Immunopathogenesis and immunotherapy of Culicoides hypersensitivity in horses: an update
Veterinary Dermatology, Volume 32, Issue 6, Page 579-e156, December 2021., 2021 Culicoides hypersensitivity (CH) is a strongly pruritic dermatitis of horses, characterised histologically by mixed perivascular to diffuse cellular infiltrates of mononuclear cells and eosinophils, and caused by helper T cell (Th)2, immunoglobulin (Ig)E‐mediated reactions to antigens present in the saliva of biting Culicoides midges.
Eliane Marti +7 more
wiley +1 more source
Immunopathogenesis of the feline atopic syndrome
Veterinary Dermatology, Volume 32, Issue 1, Page 13-e4, February 2021., 2021 Résumé Contexte Les maladies félines supposées d’origine allergique avec des phénotypes cliniques semblables, peuvent avoir de nombreuses pathogénies différentes sous jacentes. Le phénotype clinque, l’étiologie précise et l’immunopathogénie sous jacente doivent tous être considérés si des avancées veulent être faites dans ces domaines négligés de la ...
Richard Halliwell +3 more
wiley +1 more source
COVID-19: Compreendendo a “tempestade de citocinas”
Research, Society and Development, 2021 O SARS-CoV-2 espalhou-se rapidamente pela China e logo recebeu atenção mundial, levando a Organização Mundial da Saúde (OMS) a declarar, em 30 de janeiro de 2020, a infecção pelo SARS-CoV-2 como emergência de saúde pública de interesse internacional.
Raffaela Neves Mont'Alverne Napoleão +4 more
openaire +2 more sources
Citocinas, integrinas e patogenia da malária [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 1989 35^ ]infocitos T1^ B' e celulas NK2^. Em consequencia, varias citocinas sao produzidas e liberadas por estas celulas, inclusive as interleucinas (IL), interferons (IFN) e fatores de necrose tumoral (FNT), alem de diversos fatores de crescimento. As citocinas, agindo atraves de suas acoes autocrinas e paracrmas, em concentracoes minimas, sao essenciais ...
Tosta, Carlos Eduardo +1 more
openaire +3 more sources