Results 11 to 20 of about 31,058 (190)
Citoquinas: de fieles aliadas a temibles enemigas [PDF]
, 2011 Carrasco Otero, Librado
openaire +2 more sources
Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023 Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki +4 more
wiley +1 more source
Veterinary Dermatology, Volume 33, Issue 4, Page 329-e77, August 2022., 2022 Background– Cannabidiol (CBD) and cannabidiolic acid (CBDA) are reported to have antinociceptive, immunomodulatory and anti‐inflammatory actions. Objectives – To determine if CBD/CBDA is an effective therapy for canine atopic dermatitis (cAD). Conclusions and clinical relevance – Cannabidiol/CBDA as an adjunct therapy decreased pruritus, and not skin ...
Melissa Loewinger +4 more
wiley +1 more source
Altered plasma cytokines in dogs with atopic dermatitis
Veterinary Dermatology, Volume 33, Issue 2, Page 131-e38, April 2022., 2022 Background – Canine (Canis lupus familiaris) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, Regulatory T (Treg) cells, eosinophils, mast cells and other immune components.
Hamutal Mazrier +3 more
wiley +1 more source
Onset and duration of action of lokivetmab in a canine model of IL‐31 induced pruritus
Veterinary Dermatology, Volume 32, Issue 6, Page 681-e182, December 2021., 2021 Onset of antipruritic action of lokivetmab in dogs. Laboratory‐bred beagle dogs were dosed subcutaneously with either placebo or lokivetmab at 2.0 mg/kg on Day (D) 0. Approximately 2.5 h post‐dosing, pruritus was induced using canine interleukin (IL)‐31. Animals were observed for pruritic behaviours for a total of 2 h (3–5 h post‐treatment with placebo
Timothy J. Fleck +6 more
wiley +1 more source
Immunopathogenesis and immunotherapy of Culicoides hypersensitivity in horses: an update
Veterinary Dermatology, Volume 32, Issue 6, Page 579-e156, December 2021., 2021 Culicoides hypersensitivity (CH) is a strongly pruritic dermatitis of horses, characterised histologically by mixed perivascular to diffuse cellular infiltrates of mononuclear cells and eosinophils, and caused by helper T cell (Th)2, immunoglobulin (Ig)E‐mediated reactions to antigens present in the saliva of biting Culicoides midges.
Eliane Marti +7 more
wiley +1 more source
Immunopathogenesis of the feline atopic syndrome
Veterinary Dermatology, Volume 32, Issue 1, Page 13-e4, February 2021., 2021 Résumé Contexte Les maladies félines supposées d’origine allergique avec des phénotypes cliniques semblables, peuvent avoir de nombreuses pathogénies différentes sous jacentes. Le phénotype clinque, l’étiologie précise et l’immunopathogénie sous jacente doivent tous être considérés si des avancées veulent être faites dans ces domaines négligés de la ...
Richard Halliwell +3 more
wiley +1 more source
Tormenta de citoquinas: reacción adversa inhabitual por rituximab. Caso clínico [PDF]
Revista médica de Chile, 2017 Rituximab is a plausible alternative first-line treatment of ANCA-associated vasculitis. Adverse effects related to its infusion are common and usually have a benign course. However, there have been reports of refractory cardiogenic shock simulating septic shock. We report an 81-year-old male with the diagnosis of ANCA associated vasculitis.
Estefanía Palma +6 more
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Por que estrógeno e raloxifeno melhoram a densidade mineral óssea?: mecanismo de ação do estrógeno e de um modulador seletivo do receptor de estrógeno (SERM) no osso [PDF]
, 2000 Estrogen deficiency is responsible for increased bone turnover in the postmenopausal period, and it can be prevented by estrogen replacement therapy. The way by which estrogen acts on bone cells is not fully understood and there are still many unsolved ...
Cohen-Solal, Martine E. +3 more
core +2 more sources
Iatreia, 1997 La tuberculosis continúa siendo un modelo inmunológico para estudiar las infecciones intracelulares. Entenderlos complejos mecanismos de interacción de la micobacteria con el sistema inmune del hospedero permitirá un manejo más racional de los fenómenos clínicos que se presentan en la enfermedad.
García Moreno, Luis Fernando +6 more
openaire +2 more sources