Results 41 to 50 of about 42,548 (252)
Optical characterization of the organic matter of an Andisol of the East of Antioquia, Colombia
Revista de la Facultad de Ciencias, 2018 The optical characterization of the organic matter (OM) of an Andisol obtained from selective and sequential extractions of Al, Fe and Si (potassium chloride, sodium pyrophosphate, ammonium acid oxalate, dithionite-citrate-bicarbonate and sodium ...
Nicolás Pérez Echavarría +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
New therapeutic opportunities in improving the antenatal management of obese women
Репродуктивная эндокринология, 2023 Research objectives: to assess the effectiveness of the developed treatment complex on the course of pregnancy and childbirth in obese women. Materials and methods.
I.A. Zhabchenko +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Dissolution behaviour and mechanism of fly ash in acid activators
CementClarifying the dissolution behaviour and mechanism of fly ash in acid activators is essential to understand the properties of fly ash-based silico-aluminophosphate geopolymer.
Mengxin Bu +3 more
doaj +1 more source
Revista Brasileira de Ciência do Solo, 2006 A gênese de horizontes coesos em solos tem explicações não consistentes e, em muitos casos, contraditórias. Objetivou-se avaliar, em solos dos tabuleiros costeiros, os possíveis mecanismos físicos, químicos e mineralógicos que ocasionam o endurecimento ...
Ana Maria Souza dos Santos Moreau +3 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question about how timely and precise ...
Xujun Liu +22 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin +6 more
wiley +1 more source