Results 221 to 230 of about 141,868 (334)

The effect of acetyl tributyl citrate on coronary heart disease: a comprehensive computational analysis. [PDF]

BMC Pharmacol Toxicol
Ma X, Liu Y, Hua Z, Jiang F, Shi S, Wang K, Yu J, Zhang L.   +7 more
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Preparation of Diosgenin-Functionalized Gold Nanoparticles: From Synthesis to Antitumor Activities. [PDF]

Int J Mol Sci
Stolarczyk EU, Strzempek W, Muszyńska M, Kubiszewski M, Witkowska AB, Trzcińska K, Wojdasiewicz P, Stolarczyk K.   +7 more
europepmc   +1 more source

Supplementary Figure 10 from A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression [PDF]

Justin Chak Ting Cheung, Lok Wan Ng, Zhongxu Zhu, Bonan Chen, Stephen Li, Mingjing Xu, Xiaofan Ding, Dandan Pu, Yi Hu, Yuqing Ren, Wei Kang, Ming Li, Jason W.H. Wong, Xin Wang, Yuen‐Kit Cheng, Wei Shen Aik, Hoa K. Chau, Simon S.M. Ng, Nathalie Wong, Yujuan Dong   +19 more
openalex   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Citrate: a key signalling molecule and therapeutic target for bone remodeling disorder. [PDF]

Front Endocrinol (Lausanne)
Liu Q, Xue Y, Guo J, Tao L, Zhu Y.
europepmc   +1 more source

ATP-citrate lyase is essential for macrophage inflammatory response

, 2013
Vittoria Infantino, Vito Iacobazzi, Ferdinando Palmieri, Alessio Menga   +3 more
openalex   +2 more sources

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Uniport of anionic citrate and proton consumption in citrate metabolism generates a proton motive force in Leuconostoc oenos

, 1994
Ana Ramos, Bert Poolman, Helena Santos, Juke S. Lolkema, W N Konings   +4 more
openalex   +2 more sources

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source