Results 51 to 60 of about 8,793 (306)

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Urinary alkalisation for uncomplicated urinary tract infection (Protocol) [PDF]

, 2013
This is the protocol for a review and there is no abstract. The objectives are as follows:We aim to look at the benefits and harms of the use of urinary alkalisers for the treatment of uncomplicated UTIs in adult ...
Bleidorn, Brumfitt, Burian, Carlsson, Foxman, Foxman, Franz, Gupta, Higgins, Mazzulli, Munday, Richards, Spooner, Zhanel   +13 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

EVALUATION ANTIBACTERIAL AND ANTIBIOFILM ACTIVITY OF Cymbopogon citrates L. ON FIMA AND PAPC GENES AGAINST Escherichia coli

The Iraqi Journal of Agricultural science
This study was aimed  to evaluated the antibacterial activity on Cymbopogon citrates ( C. citrates ) leaves extract and assessment of its effect on fimA and papC genes in Escherichia coli ( E.coli )isolates. Rotery apparatus were used to prepare aqueous
Maha A. Khalaf, A. H. I. AL-Azawi
doaj   +1 more source

Image-guided therapy using maghemite-MOF nanovectors [PDF]

, 2017
Advances in nanotechnology offer the possibility of tailored delivery of therapeutics with real-time imaging of disease. In this issue of Chem, Steunou and co-workers amalgamate the powerful MRI properties of ultra-small paramagnetic iron oxides with the
Abánades Lázaro, Isabel, Forgan, Ross F.   +1 more
core   +1 more source

Orphenadrinium dihydrogen citrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2013
In the title salt, C18H24NO+·C6H7O7−, the dihedral angle between the benzene rings in the cation is 74.2 (5)°. In the crystal, anion–anion O—H...O hydrogen bonds and weak O—H...O interactions form infinite chains along [100]. Between these chains, cation–anion N—H—O hydrogen bonds are observed, forming an alternate pattern of cation and anion layers ...
Manpreet Kaur, Jasinski, J. P., Keeley, A. C., Yathirajan, H. S., Siddaraju, B. P.   +4 more
openaire   +4 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

In-vitro studies of some selected botanicals and baubiofungicide on mycelial growth and conidial germination of Cercospora arachidicola and Cercosporidium personatum

International Journal of Agricultural Research, Innovation and Technology, 2013
Efforts have been made to assess some plant extracts namely, Lycopersicon esculentum, Tagetus patula, Achras sapota, Azadirachta indica, Datura metel, Cymbopogon citrates, Polyalthia longifolia, Allium sativum and Allium cepa in vitro for the management ...
M.H. Hossain
doaj   +1 more source

Citral inibe a inflamação aguda e nocicepção em camundongos: o papel dos receptores TLR4 e TLR2/DECTINA-1 [PDF]

, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.Citral (3,7-dimethyl-2,6-octadienal), um monoterpeno de cadeia aberta e principal componente bioativo do capim limão, apresenta diferentes propriedades farmacológicas, tais ...
Gonçalves, Elaine Cristina Dalazen
core