Results 61 to 70 of about 5,179 (295)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

ESTERIFICATION OF CITRIC ACID WITH ALIPHATIC ALCOHOLS С₂-С₅

Тонкие химические технологии, 2017
There is an ever increasing interest in the production and use of bio-based chemical substances for the preparation of polymeric materials designed to obtain children's toys, medical equipment and materials that are in contact with food.
S. V. Sushkova, S. V. Levanova, I. Glazko, A. Alexandrov   +3 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Effect of metal citrates on indicators of the embryotoxicity of cadmium salts in rats with combined introduction [PDF]

, 2021
The aim of the study was to determine the effect of metal citrates (cerium, zinc, iron) when combined with cadmium salts (chloride/citrate) on the embryotoxicity of cadmium in rats.
Solomenko, M.V., Halperin, O.I., Kononova, I.I., Frolova, G.M., Azarov, O.I., Nefodova, O.O., Zhitniy, M.I.   +6 more
core   +1 more source

A study of citrate and bivalirudin for anticoagulation during continuous renal replacement therapy in critically ill patients with acute kidney injury

Saudi Journal of Anaesthesia
Background: During continuous renal replacement therapy (CRRT), regional citrate anticoagulation (RCA) and bivalirudin are appealing alternatives since they provide excellent anticoagulation within the circuit without increasing the risk of bleeding ...
Deepak Yadava, Manoj Tripathi, Sujeet Rai, Deepak Malviya, Suraj Kumar, Namrata Rao, Smarika Mishra   +6 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Influence of Zinc, Selenium and Germanium citrates nanoparticles on hematological and biochemical parameters of rabbits under moderate heat stress

Climate change leads to increased environmental temperatures, which negatively affects the bodies of animals. Rabbits do not have sweat glands and are not able to regulate their body temperature, which, under conditions of heat stress, disrupts the ...
M. Yuzviak
core   +1 more source

Dipotassium tetraaquabis(μ-citrato-κ4O:O′,O′′,O′′′)nickelate(II) tetrahydrate

Acta Crystallographica Section E, 2013
The title complex, K2[Ni2(C6H5O7)2(H2O)4]·4H2O, is a dinuclear centrosymmetric anionic octahedral complex, involving citrates as tridentate and bridging ligands, and coordinating water molecules.
Hua-Gang Yao, Jia-Na Huang, Run-Kang Deng, Zhi-Bang Yao   +3 more
doaj   +1 more source

Crystal structures of two magnesium citrates from powder diffraction data

Acta Crystallographica Section E: Crystallographic Communications, 2020
The crystal structures of magnesium hydrogen citrate dihydrate, Mg(HC6H5O7)(H2O)2, (I), and bis(dihydrogen citrato)magnesium, Mg(H2C6H5O7)2, (II), have been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density ...
James A. Kaduk
doaj   +1 more source