Results 61 to 70 of about 5,151 (293)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

ESTERIFICATION OF CITRIC ACID WITH ALIPHATIC ALCOHOLS С₂-С₅

Тонкие химические технологии, 2017
There is an ever increasing interest in the production and use of bio-based chemical substances for the preparation of polymeric materials designed to obtain children's toys, medical equipment and materials that are in contact with food.
S. V. Sushkova, S. V. Levanova, I. Glazko, A. Alexandrov   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effect of metal citrates on indicators of the embryotoxicity of cadmium salts in rats with combined introduction [PDF]

, 2021
The aim of the study was to determine the effect of metal citrates (cerium, zinc, iron) when combined with cadmium salts (chloride/citrate) on the embryotoxicity of cadmium in rats.
Solomenko, M.V., Halperin, O.I., Kononova, I.I., Frolova, G.M., Azarov, O.I., Nefodova, O.O., Zhitniy, M.I.   +6 more
core   +1 more source

A study of citrate and bivalirudin for anticoagulation during continuous renal replacement therapy in critically ill patients with acute kidney injury

Saudi Journal of Anaesthesia
Background: During continuous renal replacement therapy (CRRT), regional citrate anticoagulation (RCA) and bivalirudin are appealing alternatives since they provide excellent anticoagulation within the circuit without increasing the risk of bleeding ...
Deepak Yadava, Manoj Tripathi, Sujeet Rai, Deepak Malviya, Suraj Kumar, Namrata Rao, Smarika Mishra   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Influence of Zinc, Selenium and Germanium citrates nanoparticles on hematological and biochemical parameters of rabbits under moderate heat stress

Climate change leads to increased environmental temperatures, which negatively affects the bodies of animals. Rabbits do not have sweat glands and are not able to regulate their body temperature, which, under conditions of heat stress, disrupts the ...
M. Yuzviak
core   +1 more source

Dipotassium tetraaquabis(μ-citrato-κ4O:O′,O′′,O′′′)nickelate(II) tetrahydrate

Acta Crystallographica Section E, 2013
The title complex, K2[Ni2(C6H5O7)2(H2O)4]·4H2O, is a dinuclear centrosymmetric anionic octahedral complex, involving citrates as tridentate and bridging ligands, and coordinating water molecules.
Hua-Gang Yao, Jia-Na Huang, Run-Kang Deng, Zhi-Bang Yao   +3 more
doaj   +1 more source