Results 41 to 50 of about 8,903,381 (313)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Les ambivalences d’un rêve urbain : filmer les villes du Golfe
Arabian Humanities, 2019 Based on the study of local Gulf cinema, Western cinema and South‑Asian diasporic films, this study aims to analyze the visual grammar used by film directors to interpret the new urban environment of the Oil states in the Gulf.
Thomas Richard
doaj +1 more source
City Festivals and Festival Cities [PDF]
, 2020 This chapter discusses the role of city festivals in shaping and re-imagining urban space. There has been increased interest in festivals among decision-makers and marketers as vehicles for cultural profiling, regeneration, and social inclusion. The chapter views space as inseparable from economic and social structures and practices which govern urban ...
openaire +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Interfaces multi-échelles : une approche exploratoire appliquée au littoral niçois
Territoire en Mouvement, 2021 This paper is the outcome of a think-tank on interfaces. After expounding the main formalizations, the group has come to, the authors demonstrate in a conceptual approach faced to an empirical reality, the interest of reasoning in multiscale interfaces ...
Sandra Pérez +5 more
doaj +1 more source
City of Cooper City Proclamation [PDF]
, 2013 NSU 50th Anniversaryhttps://nsuworks.nova.edu/nsudigital_proclamations/1037/thumbnail ...
City of Cooper City
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Social Consequences of the Growth of Kazakhstan’s Megapolises and Recommendations for Overcoming
Экономика: стратегия и практика, 2022 The purpose of the article was to study changes in living conditions in megapolises as they grow, identify negative social consequences and develop recommendations for overcoming them.
A. Tleuberdinova +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source