Results 61 to 70 of about 1,506,593 (310)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Identity of youth of an industrial city in historical and social contexts (the case of Leninogorsk)
Историческая этнологияThe article examines the formation and manifestation of the identity of the youth of an industrial city using Leninogorsk as an example. The attitude of young people towards the town is affected, above all else, by the social opportunities it provides ...
Elvira R. Kalimullina
doaj +1 more source
Representing Iranian-Islamic Identity in Iranian Contemporary Cities Structure
Journal of Contemporary Urban Affairs, 2019 Urban identity could be considered as the result of interaction between social identity system and urbanism system. The term “Islamic City” is defined only by considering the physics of the city and reducing the concept of the city to physical elements ...
MARYAM KAMYAR, ZAHRA JAFARI SPOUREZI
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Locus branding as an element of territorial marketing of Caucasian Mineral Waters Resort towns
Современная наука и инновацииThe city as a part of the socio-cultural space has its own uniqueness, which is expressed in the formation of its image. "Locus branding" (branding of the territory) is detailed by such concepts as "identity of the city", "identity of the territory ...
A. V. Baturov, V. F. Kshishnevskaya
doaj +1 more source
Sounds of the City: Dramaturgy, Space, Identity
Critical Stages, 2021 This article offers a response to the question, “How can we think about cities within the frame of a dramaturgy of sound?” Drawing on our scholarly interest in cities, we, the authors, consider how city meanings are produced and transmitted through music
Katie Beswick, Javon Johnson
doaj
Labour market experiences of young UK Bangladeshi men: Identity, inclusion and exclusion in inner-city London [PDF]
, 2008 Detailed qualitative data are used to explore the processes perpetuatinglabour market disadvantage among young UK-Bangladeshi men living in central London.
Alexander C. +29 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cultural Identity and Knowledge Creation in Cosmopolitan Cities [PDF]
SSRN Electronic Journal, 2009 ABSTRACTWe study how the city system is affected by the possibility for the members of the same cultural diaspora to interact across different cities. In so doing, we propose a simple two‐city model with two mobile cultural groups. A localized externality fosters the productivity of individuals when groups interact in a city.
PRAROLO, GIOVANNI +1 more
openaire +6 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source