Results 51 to 60 of about 240,957 (219)

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang   +9 more
wiley   +1 more source

Single‐Atom Pt Anchoring on Self‐Doped ZrO2@G‐C3N4 Nanostructure Enables Efficient Photocatalytic Seawater Hydrogen Evolution

open access: yesAdvanced Science, EarlyView.
Grain‐like Zr3+‐ZrO2 and Pt single atoms are integrated into an S‐scheme Zr3+‐ZrO2@g‐C3N4 heterostructure to enable efficient visible‐light‐driven seawater hydrogen production. The combined effect of Pt single‐atom sites and the S‐scheme charge‐transfer pathway accelerates carrier separation, preserves strong redox ability, and markedly enhances ...
Hezheng Sun   +8 more
wiley   +1 more source

The temporary use as a strategy for transforming the space of contemporary cities. Space transformations supported by the purposeful application of temporary use, based on a case study

open access: yesMiscellanea Geographica: Regional Studies on Development, 2018
Temporary use as a subject of work should be understood as temporary development or use of land and facilities, in a way that allows the best use of spatial resources at a given time and place.
Szaton Karolina Marta
doaj   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

open access: yesAdvanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin   +2 more
wiley   +1 more source

Study of Free‐Space Optical Quantum Network: Review and Prospectives

open access: yesAdvanced Science, EarlyView.
Free from the constraints of fiber connections, free‐space quantum network enables longer and more flexible quantum network connections. This review summarizes and comparatively analyzes free‐space quantum network experiments based on ground stations, satellites, and mobile platforms.
Hua‐Ying Liu, Zhenda Xie, Shining Zhu
wiley   +1 more source

Selective State DOT Lane Width Standards and Guidelines to Reduce Speeds and Improve Safety

open access: yesInfrastructures
This research investigates the lane width standards and guidelines implemented by various State Departments of Transportation (DOTs) to reduce vehicle speeds and enhance road safety. Lane width reduction is often perceived as a strategy to mitigate speed
Reid Ewing   +4 more
doaj   +1 more source

La mixité sociale à l’épreuve des nouvelles temporalités

open access: yesEspace populations sociétés, 2007
The public policy was limited during a long time at the restructuring of working hours. And today, it takes in consideration the asking for an improvement of comfort, the preoccupation for a durable development and the arrival of a lot of inactive people.
Jean-Marie Allain
doaj   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

open access: yesAdvanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi   +7 more
wiley   +1 more source

Neighborhood socio-environmental vulnerability and infant mortality in Hermosillo, Sonora Vulnerabilidad socioambiental y mortalidad infantil en barrios de Hermosillo, Sonora

open access: yesSalud Pública de México, 2012
OBJECTIVE: This paper explores the impact of contextual variables at the neighborhood level on a health marker in the city of Hermosillo, Mexico and discusses the importance of collaboration between planners and health professional to minimize the ...
Francisco Lara-Valencia   +4 more
doaj  

Spatial organization of the tourist destination «The Capital of the Don Cossacks»

open access: yesАрхитектон
The spatial organization of touristic destination «The Capital of the Don Cossacks» is examined within the boundaries of the Lower Don. On the basis of an interdisciplinary approach, including the use of methods of spatial, historical-genetic, planning ...
Daniil S. Alekseev   +2 more
doaj   +1 more source

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