Results 41 to 50 of about 73,474 (265)
An Intelligent Advisor for City Traffic Policies [PDF]
, 2018 Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This research has been partially funded by the Spanish MINECO and FEDER projects TIN2014-57341-R, TIN2016-81766-REDT, and TIN2017-88213-R. University of Malaga, Andalucia TECH. Daniel H. Stolfi is supported by a FPU grant (FPU13/00954) from the Spanish MECD. Christian Cintrano is
Daniel H. Stolfi +3 more
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Advanced Science, EarlyView.Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang +8 more
wiley +1 more source
Policies to Reduce Traffic Externalities in Cities [PDF]
SSRN Electronic Journal, 2012 This paper considers various policy measures to reduce traffic externalities in cities, including externality-reducing investments, tolls, emission standards, low emission zones, and bypass capacity to guide traffic around the city center. Using a simple model that distinguishes local and through traffic, we study the optimal use of these instruments ...
DE BORGER, Bruno, PROOST, Stef
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mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, EarlyView.Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source
تحقيقات جغرافيايی, 2016 Though city life and machining living of human beings has some advantage and facilities, yet it has caused a lot of problems as city heavy traffic, along with unanticipated growth of population and unusual development of cities, on the one side and the ...
Mohsen Saghaei +2 more
doaj
HeliyonThe transportation environment of smart cities is complex and ever-changing, and traffic flow is influenced by various factors. With the increase of traffic flow in smart cities, optimizing traffic intersection signal control has become an important ...
Jingya Wei, Yongfeng Ju
doaj +1 more source
Planning Urban Internal Transport Based on Cell Phone Data
Applied Sciences, 2022 Based on cell phone data, mining residents’ travel characteristics and regional traffic connection characteristics has become an important technology for urban road traffic planning research. Based on cell phone data extracted from Wuxue City, this paper
Hong Xu, Jin Zhao
doaj +1 more source
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, EarlyView.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
Forensic Analysis of 498 Road Traffic Accident Deaths in Haikou City [PDF]
Fayixue Zazhi, 2017 Objective To analyse the characteristics of road traffic accident deaths in Haikou city, and to provide reference for the identification of causes of death and the preventive measures.
BAI RU, CHEN MING
doaj +1 more source
Advanced Science, EarlyView.Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim +9 more
wiley +1 more source