Results 181 to 190 of about 103,639 (259)

Environmental impacts of metro rail construction in chennai on air quality noise pollution and urban sustainability. [PDF]

open access: yesSci Rep
Das A   +5 more
europepmc   +1 more source

Multi‐Scale Hybrid Modeling to Predict Cell Culture Process With Metabolic Phase Transitions

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT To advance understanding of cellular metabolism and reduce batch‐to‐batch variability in cell culture processes, this study introduces a multi‐scale hybrid modeling framework designed to simulate and predict the dynamic behavior of CHO cell cultures undergoing metabolic phase transitions.
Keqi Wang, Sarah W. Harcum, Wei Xie
wiley   +1 more source

On the Prediction of pDNA Productivity Across Diverse Bioprocesses Using Ensemble Hybrid Models

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT The global demand for plasmid DNA (pDNA) is rapidly increasing due to its key role in the manufacture of mRNA vaccines and advanced therapy medicinal products (ATMPs). However, the reliance on suboptimal batch and/or fed‐batch processes, as well as the diversity and increasing complexity of plasmid constructs pose significant challenges during
Nikolaos Stratis   +2 more
wiley   +1 more source

Impact of Agitation Power Input on Aspergillus oryzae Metabolism: Application of Multi‐Omics on an Industrial Enzyme Fermentation

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino   +6 more
wiley   +1 more source

Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo   +3 more
wiley   +1 more source

Thermodynamic Evaluation of Dual Substrate Growth

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Various C₁–C₂ compounds are increasingly available through electrochemical reduction of CO2. Although not always suitable as a sole substrate, these compounds can supplement a primary substrate like glucose to enhance microbial growth. Yet, the mechanisms underlying the effects of dual substrate consumption on growth rate and growth yield ...
Marit A. Verheijen   +3 more
wiley   +1 more source

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