Results 201 to 210 of about 696,030 (310)

Journal of Civil Engineering and Environmental Sciences [PDF]

open access: yesJournal of Civil Engineering and Environmental Sciences, 2018
openaire   +1 more source

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier   +3 more
wiley   +1 more source

Culvert Retrofit with Green Filter Media for the Removal of Phosphorus from Stormwater Runoff. [PDF]

open access: yesMaterials (Basel)
Bagchi S   +7 more
europepmc   +1 more source

Multimodal Chromatography in the Downstream Processing of mAb‐Based Products: Mechanisms, Strategies, and Applications

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan   +4 more
wiley   +1 more source

Mediated Electrochemical Probing and Machine Learning for Cysteine and Reduced Monoclonal Antibody Quantification

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Biopharmaceutical manufacturing requires robust analytics and process controls throughout production to insure high yield of quality products. New methodologies for rapidly accessing and integrating data‐rich information from complex dynamic biological environments are of great interest.
Kayla Chun   +8 more
wiley   +1 more source

Evaporative Losses of Perfluoroalkyl Sulfonamides during PFAS Analysis. [PDF]

open access: yesACS Omega
Dixit F   +7 more
europepmc   +1 more source

Hidden O‐Deglycosylation Activity Triggers O → C Rearrangement for Aryl Di‐C‐Glucoside Formation by the C‐Glycosyltransferase From Fortunella crassifolia

open access: yesBiotechnology and Bioengineering, EarlyView.
Here, we uncovered an unexpected O‐deglycosylation activity of the C glycosyltransferase (FcCGT), forming phloretin (1) from phloretin 2'‐O‐glucoside (2). In the presence of UDP, FcCGT catalyzes the O→C rearrangement to yield nothofagin (3). Upon additional UDP‐glucose, further C‐glycosylation occurs, forming phloretin 3',5'‐di‐C‐glucoside (4 ...
Tuo Li   +4 more
wiley   +1 more source

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