Results 151 to 160 of about 3,483,527 (302)
Biotechnology and Bioengineering, EarlyView.ABSTRACT Debaryomyces hansenii is a yeast with diverse potential applications like producing oleochemicals from biomass. Yet, combinatorial metabolic engineering in D. hansenii is limited because, like many nonconventional organisms, key genomic data and genetic elements are missing. Here, we report phenotypic characterization, genomic integration loci,
Zekun Li +3 more
wiley +1 more source
An empirical examination of liability for ecological environment restoration in the context of the Civil Code of China. [PDF]
HeliyonSong F, Zhang K, Song B.
europepmc +1 more source
Les évolutions écologiques des codes civils étrangers : L’exemple du Code civil belge
Présentation des réformes récentes du Code civil belge en lien avec l'Anthropocène : ordre public environnemental, troubles de voisinage mais absence de préjudice ...
de Clippele, Marie-Sophie +1 more
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Biotechnology and Bioengineering, EarlyView.ABSTRACT Generation of CAR‐T cell therapies relies predominantly on lentiviral vectors (LVs). As in vivo CAR‐T trials progress, demand for larger quantities of higher‐potency LV is expected. However, primary capture by anion‐exchange chromatography (AIEX) remains a major manufacturing bottleneck from use of adsorbents not tailored to LVs, leading to ...
George Pamenter +10 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga +2 more
wiley +1 more source
Autonomous Control of Gene Expression Using Endogenous Transcription Signals
Biotechnology and Bioengineering, EarlyView.ABSTRACT Autonomous cell‐based control of heterologous gene expression can simplify batch‐culture bioprocessing by eliminating external monitoring and extrinsic control of culture conditions. Existing approaches use auto‐induction media, synthetic cell‐cell communication systems, or application‐specific biosensors.
Pakpoom Subsoontorn +2 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Antibody productivity and glycosylation quality in CHO cell cultures emerge from a dynamically evolving metabolic environment, yet existing models often work in isolation or at a single scale. Here, we present a multiscale mechanistic framework linking molecular, cellular, and macroscopic scales to predict how inputs shape bioprocess ...
Yuming Zeng +3 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT A method to select Escherichia coli citrate synthase variants having reduced activity was developed based initially on the increased generation of acid, observed visually by prolonged color change in the pH indicator bromocresol purple. Five hundred fifty‐two potential variants were isolated and each were cultured on glucose as sole carbon ...
Jeffrey K. Dodelin +3 more
wiley +1 more source
Translation: Tort Liability – Section 7 – Civil Code of the People’s Republic of China
, 2020 Conk GW.
europepmc +1 more source