Results 51 to 60 of about 310,389 (304)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Phylogenomic analysis of the Candida auris-Candida haemuli clade and related taxa in the Metschnikowiaceae, and proposal of thirteen new genera, fifty-five new combinations and nine new species.

Persoonia
Candida is a polyphyletic genus of asexually reproducing yeasts in the Saccharomycotina with more than 400 species that occur in almost all families of the subclass and its name is strongly connected with the infectious disease candidiasis.
F. Liu, Z-D Hu, X-M Zhao, W-N Zhao, Z-X Feng, A. Yurkov, S. Alwasel, T. Boekhout, K. Bensch, F. Hui, F. Bai, Q.-M. Wang   +11 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Fenestelloid clades of the Cucurbitariaceae [PDF]

Persoonia - Molecular Phylogeny and Evolution of Fungi, 2020
Fresh collections and their ascospore and conidial isolates backed up by type studies and molecular phylogenetic analyses of a multigene matrix of partial nuSSU-, complete ITS, partial LSU rDNA, rpb2, tef1 and tub2 sequences were used to evaluate the boundaries and species composition of Fenestella and related genera of the Cucurbitariaceae.
Jaklitsch, W.M., Voglmayr, H. (Hermann)
openaire   +6 more sources

Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study.

The Lancet Microbe
BACKGROUND The emerging fungal pathogen Candida auris poses a serious threat to global public health due to its worldwide distribution, multidrug resistance, high transmissibility, propensity to cause outbreaks, and high mortality.
Chayaporn Suphavilai, K. Ko, K. Lim, M. Tan, Patipan Boonsimma, Joash Jun Keat Chu, S. Goh, Prevena Rajandran, L. Lee, K. Tan, Bushra Binte Shaik Ismail, M. K. Aung, Yong Yang, J. Sim, I. Venkatachalam, B. Cherng, Bram Spruijtenburg, K. Chan, L. Oon, Ai Ling Tan, Y. Tan, L. Wijaya, Ban Hock Tan, Moi Lin Ling, T. H. Koh, J. Meis, C. Tsui, Niranjan Nagarajan   +27 more
semanticscholar   +1 more source

Evolution, global spread, and pathogenicity of highly pathogenic avian influenza H5Nx clade 2.3.4.4

Journal of Veterinary Sciences, 2017
Novel subtypes of Asian-origin (Goose/Guangdong lineage) H5 highly pathogenic avian influenza (HPAI) viruses belonging to clade 2.3.4, such as H5N2, H5N5, H5N6, and H5N8, have been identified in China since 2008 and have since evolved into four ...
Dong‐Hun Lee, K. Bertran, J. Kwon, D. Swayne   +3 more
semanticscholar   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Clade I Monkeypox virus genomic diversity in the Democratic Republic of the Congo, 2018 - 2024: Predominance of Zoonotic Transmission

medRxiv
Background: Recent reports raise concerns on the changing epidemiology of mpox in the Democratic Republic of the Congo (DRC), with increasing case counts, sexual contact-mediated clusters, and sustained human-to-human transmission driven by a novel ...
E. Kinganda-Lusamaki, A. Amuri-Aziza, Nicolas Fernandez-Nuñez, J. Makangara-Cigolo, Catherine Pratt, E. Vakaniaki, N. Hoff, Gradi Luakanda-Ndelemo, P. Akil-Bandali, Sabin S Nundu, N. Mulopo-Mukanya, Michel Ngimba, Brigitte Modadra-Madakpa, Ruth Diavita, Princesse Paku-Tshambu, E. Pukuta-Simbu, Sydney Merritt, Á. O'toole, N. Low, A. Nkuba-Ndaye, H. Kavunga-Membo, Robert Shongo Lushima, Laurens Liesenborghs, T. Wawina-Bokalanga, K. Vercauteren, D. Mukadi-Bamuleka, L. Subissi, J. Muyembe‐Tamfum, J. Kindrachuk, A. Ayouba, A. Rambaut, Eric Delaporte, S. Tessema, Eric D’Ortenzio, Anne W Rimoin, Lisa E Hensley, P. Mbala-Kingebeni, M. Peeters, S. Ahuka-Mundeke   +38 more
semanticscholar   +1 more source

Biodegradable and Recyclable Luminescent Mixed‐Matrix‐Membranes, Hydrogels, and Cryogels based on Nanoscale Metal‐Organic Frameworks and Biopolymers

Advanced Functional Materials, EarlyView.
The study presents biodegradable and recyclable mixed‐matrix membranes (MMMs), hydrogels, and cryogels using luminescent nanoscale metal‐organic frameworks (nMOFs) and biopolymers. These bio‐nMOF‐MMMs combine europium‐based nMOFs as probes for the status of the materials with the biopolymers agar and gelatine and present alternatives to conventional ...
Moritz Maxeiner, Julian Burkhart, Kateryna Borysova, Chiara Mazzariol, Klaus Müller‐Buschbaum   +4 more
wiley   +1 more source

Gait Analysis of Pak Biawak: A Necrobot Lizard Built using the Skeleton of an Asian Water Monitor (Varanus Salvator)

Advanced Robotics Research, EarlyView.
Pak Biawak, a necrobot, embodies an unusual fusion of biology and robotics. Designed to repurpose natural structures after death, it challenges conventional boundaries between nature and engineering. Its movements are precise yet unsettling, raising questions about sustainability, ethics, and the untapped potential of biointegrated machines.
Leo Foulds, Donan Satria Yudha, Parvez Alam   +2 more
wiley   +1 more source