Results 61 to 70 of about 6,848 (153)

Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis

Drug Design, Development and Therapy, 2019
Anqi Zhou, Qi Han, Huihui Song, Jie Zi, Jinlong Ma, Zheng GeDepartment of Hematology, Zhongda Hospital Southeast University, Institute of Hematology Southeast University, Nanjing 210009, People’s Republic of ChinaPurpose: To investigate the overall
Zhou A, Han Q, Song H, Zi J, Ma J, Ge Z
doaj  

The efficacy of cladribine tablets in CIS patients retrospectively assigned the diagnosis of MS using modern criteria: Results from the ORACLE-MS study

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2017
Background Multiple sclerosis (MS) diagnostic criteria have changed since the ORACLE-MS study was conducted; 223 of 616 patients (36.2%) would have met the diagnosis of MS vs clinically isolated syndrome (CIS) using the newer criteria.
Mark S Freedman, Thomas P Leist, Giancarlo Comi, Bruce AC Cree, Patricia K Coyle, Hans-Peter Hartung, Patrick Vermersch, Doris Damian, Fernando Dangond   +8 more
doaj   +1 more source

Possible Reasons for the Suboptimal Response of the Cladribine Course in Daily Practice: An Independent Analysis of Data from 12 Russian Clinics and the Results of Post-Registration Studies in Other Countries

Sclerosis
Objectives: The purpose of this study was to analyze the effect of daily intake of cladribine tablets on the course of multiple sclerosis (MS) while monitoring for 1–4 years during and after the course in several neurological clinics from different ...
Alexey N. Boyko, Valentina M. Alifirova, Daria V. Pashkovskaya, Ekaterina I. Kuchina, Stella A. Sivertseva, Elena L. Turova, Zoya A. Goncharova, Olga Yu Rudenko, Yulia Yu Pogrebnova, Farid A. Khabirov, Timur I. Khaibullin, Natalia N. Babicheva, Natalia L. Khoroshilova, Oksana V. Dzundza, Olga A. Soldatova, Anna N. Belova, Gennadyi E. Sheiko, Anastasia E. Makarova, Natalia G. Glavinskaya   +18 more
doaj   +1 more source

Experience with the use of cladribine tablets in real-life clinical practice: independent analysis of data from 12 Russian clinical centres

Неврология, нейропсихиатрия, психосоматика
Multiple sclerosis (MS) is an autoimmune-inflammatory and neurodegenerative disease of the central nervous system. The article analyses the ability of cladribine, which due to its selective lymphotoxic effect on activated cells and central effect on ...
A. N. Boyko, V. M. Alifirova, D. V. Pashkovskaya, E. I. Kuchina, S. A. Sivertseva, E. L. Turova, Z. A. Goncharova, O. Yu. Rudenko, Yu. Yu. Pogrebnova, F. A. Khabirov, T. I. Khaibullin, N. N. Babicheva, N. L. Khoroshilova, O. V. Dzundza, O. A. Soldatova, A. N. Belova, G. Е. Sheiko, A. Е. Makarova, N. G. Glavinskaya   +18 more
doaj   +1 more source

A multi-country cohort database study to assess pregnancy and infant outcomes after potential maternal or paternal exposure to cladribine tablets in the treatment of multiple sclerosis: the CLEAR study methods and status update

Therapeutic Advances in Neurological Disorders
Background: Cladribine tablets are contraindicated during pregnancy; therefore, safety data on pregnancies exposed to this treatment are limited. CLEAR collects and describes pregnancy outcomes in this understudied population. Objectives: To describe the
Kerstin Hellwig, Melinda Magyari, Thomas M. MacDonald, Carolyn E. Cesta, Stig Wergeland, Maarit K. Leinonen, Asher Ornoy, Sandra Vukusic, Alexandra Lauer, Xiaolei Zhou, Alison Kawai, Rachel Weinrib, Alejandro Arana, Tahani Boumenna   +13 more
doaj   +1 more source

Bilateral Herpetic Keratitis following Cladribine Immunosuppression: A Case Report

Case Reports in Ophthalmology
Introduction: Disease-modifying therapies for multiple sclerosis (MS), including cladribine, alter immune function and may increase susceptibility to viral reactivation. While herpesvirus infections have been reported with cladribine, herpetic
Hanna Pawlowski, Cole S. Elsner, Sanjana Molleti, Calisa G. Lee-Choi, Mina M. Sitto, Phillip C. Hoopes, Majid Moshirfar   +6 more
doaj   +1 more source

Cladribine Ameliorates Imiquimod Induced Murine Psoriasiform Dermatitis

Clinical, Cosmetic and Investigational Dermatology
Jingwen Xue,1,2 Dan Shu,1,2 Yi Zhao1,2 1Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, People’s Republic of China; 2Photomedicine Laboratory, Institute of Precision ...
Xue J, Shu D, Zhao Y
doaj  

Exploring adenosine analogs for chondrosarcoma therapy: In vitro and in vivo insights

Molecular Therapy: Nucleic Acids
Chondrosarcomas (CSs) are resistant to conventional chemotherapy and radiotherapy. Therefore, new therapeutic approaches are needed. The aim of this study was to validate the use of adenosine analogs as a new therapeutic strategy for the treatment of CS.
Marion Lenté, Juliette Aury-Landas, Mahdia Taieb, Benoît Bernay, Eva Lhuissier, Karim Boumédiene, Catherine Baugé   +6 more
doaj   +1 more source

Cladribine tablets after treatment with natalizumab (CLADRINA) – rationale and design

Therapeutic Advances in Neurological Disorders
Background: Individual disease modifying therapies approved for multiple sclerosis (MS) have limited effectiveness and potentially serious side effects, especially when administered over long periods.
Peter V. Sguigna, Rehana Z. Hussain, Annette Okai, Kyle M. Blackburn, Lauren Tardo, Mariam Madinawala, Julie Korich, Lori A. Lebson, Jeffrey Kaplan, Amber Salter, Navid Manouchehri, Olaf Stuve   +11 more
doaj   +1 more source

Weekly Cladribine Followed by Rituximab for the Treatment of Hairy Cell Leukemia. [PDF]

EJHaem
Turner JA, Santos J, Pizzuti V, Paton E, Robinson WA.   +4 more
europepmc   +1 more source