Results 61 to 70 of about 3,785 (242)

Analysis of premature failure of a tie bar in an injection molding machine

, 2006
Premature failure of a tie bar made of AISI 4140 steel in a 150 tonne plastic injection-molding machine has been analyzed. Although the nominal tensile stress acting on the tie bars (95.5 MPa) is far lower than the yield strength of this material (750 ...
Srikanth, S, Das, S K, Sasikumar, C
core   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Clamp Tie and Surgery Bucket Module: Surgical Bucket Ingredient List

, 2018
"Clamp and Tie Module Goal: residents should be able to pass a silk tie atraumatically around a clamped structure and tie into a hole. Clamp and Tie Module Instructions: (Can be completed solo or with partner): 1.
Peter Bartline MD; Ruth Braga MSN; William Peche MD; Daniel Vargo MD
core  

Hemostasis Technique Using an Adjustable Nylon Tie in Dog with Splenic Hematoma and Lymphoid Hyperplasia [PDF]

, 2017
Background: Splenic hematoma is an encapsulated blood accumulation, which is macroscopically indistinguishable from malignant spleen. The treatment of choice and final diagnosis were by splenectomy and exploratory laparotomy followed by biopsy and ...
de Azevedo, Maria Gabriela Picelli, da Silva, Bruna Martins, Rahal, Sheila Canevese, de Góis, Frederico Matheus Ducatti, Del Poente, Maria Duarte, Bombrini, Giovanna Cristina, Gomes, Mayara Viana Freire, dos Santos, Ivan Felismino Chagas, Tannus, Filipe Carrari Isaac   +8 more
core   +3 more sources

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Clamp Tie and Surgery Bucket Module: Figure of 8 Compiled Pics

, 2018
"Clamp and Tie Module Goal: residents should be able to pass a silk tie atraumatically around a clamped structure and tie into a hole. Clamp and Tie Module Instructions: (Can be completed solo or with partner): 1.
Peter Bartline MD; Ruth Braga MSN; William Peche MD; Daniel Vargo MD
core  

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Stapled Bowel Anastomosis Video Demonstration

, 2018
Dr. Vargo explaining techniques of a stapled bowel anastomosis. Clamp and Tie Module Goal: residents should be able to pass a silk tie atraumatically around a clamped structure and tie into a ...
Daniel Vargo, MD
core  

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Deep Vascular Anastomosis Video Demonstration

, 2018
Dr. Campsen explains the techniques of performing a deep anastomosis. Clamp and Tie Module Goal: residents should be able to pass a silk tie a-traumatically around a clamped structure and tie into a ...
Jeff Campsen, MD
core