Results 71 to 80 of about 3,785 (242)

Lightweight, Compact, Fast & Flexible Subsea Tie-Ins with HCCS-L

open access: yes, 2018
Evermore than before, there is an imminent need to simplify the subsea operations and reduce the weight, size and envelope of subsea production hardware such as XT, Manifold & distribution system.
Mohammed Hasan Ali
core   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

open access: yesAdvanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li   +12 more
wiley   +1 more source

The Mechanical Analysis of an Injection Machine Clamping Unit

open access: yes, 2010
The paper is to simulate and analyze the mechanical behavior of the clamp system of an injection molding machine. Different commercial simulation tools are combined to create complete model of the system. The flexibility of several components is included
Gang Zhang   +3 more
core   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

open access: yesAdvanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi   +8 more
wiley   +1 more source

Bale-Tie.

open access: yes, 1879
Patent for a new and improved bale tie. This design utilizes a strap-iron binder with notches along the sides that allow for a bail to clamp firmly within them; thus, the bale is ...
Johnson, Jordan
core  

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

open access: yesAdvanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu   +7 more
wiley   +1 more source

Models and a deformations simulation approach using ANSYS CAD for railway wagons weighing system

open access: yesНаучно-технический вестник информационных технологий, механики и оптики
Possibility of fast, convenient and precise definition of wagons load mass allows enhancing transport safety and ensures assets accounting in railroad infrastructure.
M. A. Denisenko   +3 more
doaj   +1 more source

LigaSure (R) versus Clamp Tie Technique for Thyroid Surgery; Decreased Operative Time versus Increased Inflammatory Effect: a prospective randomized study

open access: yes, 2014
OBJECTIVE: The aim of this study was to compare the LigaSure (R) Small Jaw Instrument (LSJI) with the conventional clamp-and-tie (CT) technique in thyroid surgery regarding complication rates (hematoma, hypocalcemia and recurrent nerve palsy), the ...
Moray, G.   +6 more
core  

42" Subsea Connector & Open-PLET Technology

open access: yes, 2018
With the increasing demand in the gas field developments around the world which typically characterizes a large diameter subsea to shore gas export pipelines, tie-in connectors become necessary to be able provide to connection between various subsea ...
Mohammed Hasan Ali
core   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

open access: yesAdvanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu   +13 more
wiley   +1 more source

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