Results 41 to 50 of about 237,278 (295)

Amplifier clamping circuit for horizon scanner Patent [PDF]

open access: yes, 1967
Clamped amplifier circuit for horizon scanner enabling amplification and accurate measurement of specified ...
Cantor, C.
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Layerwise generalized formulation solved via a boundary discontinuous method for multilayered structures. Part 1: Plates

open access: yesCurved and Layered Structures
This article presents for the very first time a layerwise bending analytical solution for cross-ply laminated composite plates with clamped boundary conditions at all edges.
Laureano Ronaldo Walter   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Asymptotic analysis of the clamped-pinned elastica

open access: yesArchives of Mechanics, 2018
Asymptotic solutions for the clamped-pinned elastica when the displacement of the pinned end is small (immediately after buckling) and when it approaches its limiting displacement (when the force in the rod tends to infinity) are presented.
P. Singh, V.G.A. Goss
doaj   +1 more source

Strain Behavior at Crack Tip in Thin Plate Using Numerical and Experimental Work [PDF]

open access: yesEngineering and Technology Journal, 2016
In this work, strains were studied and analyzed in a thin flat plate with a surface crack at the center, subjected to cycling of low velocity impact loading for two types of aluminum plates (2024, 6061).
Fathi A.Alshamma, Bassam Ali Ahmed
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Active Structural Acoustic Control of Clamped Flat Plates Using a Weighted Sum of Spatial Gradients

open access: yesShock and Vibration, 2015
The weighted sum of spatial gradients (WSSG) control minimization parameter is developed for use in active structural acoustic control (ASAC) on a clamped flat rectangular plate.
William R. Johnson   +3 more
doaj   +1 more source

THERMOMECHANICAL BEHAVIOR OF A THICK THREE–LAYER CYLINDRICAL PANEL WITH RIGIDLY CLAMPED ENDS [PDF]

open access: yes, 2018
To investigate the thermomechanical behavior of a thick three-layer cylindrical panel with rigidly clamped ...
ZAVGORODNIY, Andriy
core  

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz   +3 more
wiley   +1 more source

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