Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A [PDF]
Nature Communications, 2016 Hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a critical factor for HCV RNA replication. Here the authors show that SCOTIN, an interferon beta-inducible host protein, functions to limit HCV replication by targeting viral protein NS5A for ...
Nari Kim +5 more
doaj +2 more sources
Protein Kinase C Inhibitors Reduce SARS-CoV-2 Replication in Cultured Cells
Microbiology Spectrum, 2022 Infection by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has posed a severe threat to global public health. The current study revealed that several inhibitors of protein kinases C (PKCs) possess protective activity against SARS ...
Changbai Huang +12 more
doaj +3 more sources
Regulatory Role of Phospholipids in Hepatitis C Virus Replication and Protein Function [PDF]
Pathogens, 2022 Positive-strand RNA viruses such as hepatitis C virus (HCV) hijack key factors of lipid metabolism of infected cells and extensively modify intracellular membranes to support the viral lifecycle.
Anna V. Bulankina +2 more
doaj +4 more sources
Functional Studies of CCAAT/Enhancer Binding Protein Site Located Downstream of the Transcriptional Start Site [PDF]
Clinical Medicine Insights: Pathology, 2017 Previous studies have identified a CCAAT/enhancer binding protein (C/EBP) site located downstream of the transcriptional start site (DS3). The role of the DS3 element with respect to HIV-1 transactivation by Tat and viral replication has not been ...
Yujie Liu +7 more
doaj +4 more sources
Functional study of two flexible regions of the hepatitis E virus ORF1 replicase. [PDF]
PLoS ONEHepatitis E virus (HEV), like other positive-sense RNA viruses, encodes a multidomain protein essential for replication, termed ORF1. However, the number, organization, and functions of its domains remain debated.
Léa Mézière +8 more
doaj +2 more sources
Viruses, 2022 Avian metapneumovirus subgroup C (aMPV/C) is highly pathogenic to various avian species with acute respiratory tract clinicopathology and/or drops in egg production.
Dedong Wang +8 more
doaj +1 more source
Regulation of the activity of the dual-function DnaA protein in Caulobacter crescentus. [PDF]
PLoS ONE, 2011 DnaA is a conserved essential bacterial protein that acts as the initiator of chromosomal replication as well as a master transcriptional regulator in Caulobacter crescentus.
Carmen Fernandez-Fernandez +2 more
doaj +1 more source
mBio, 2023 There is a limited understanding of host defense mechanisms targeting intracellular pathogens that proliferate in a lysosome. Coxiella burnetii is a model bacterial pathogen capable of replicating in the hydrolytic and acidic environment of the lysosome.
Sandhya Ganesan +5 more
doaj +1 more source
Drosophila RecQ4 Is Directly Involved in Both DNA Replication and the Response to UV Damage in S2 Cells. [PDF]
, 2012 The RecQ4 protein shows homology to both the S.cerevisiae DNA replication protein Sld2 and the DNA repair related RecQ helicases. Experimental data also suggest replication and repair functions for RecQ4, but the precise details of its involvement remain
Cotterill, S +6 more
core +6 more sources
C-terminal substitution of HBV core proteins with those from DHBV reveals that arginine-rich 167RRRSQSPRR175 domain is critical for HBV replication. [PDF]
PLoS ONE, 2012 To investigate the contributions of carboxyl-terminal nucleic acid binding domain of HBV core (C) protein for hepatitis B virus (HBV) replication, chimeric HBV C proteins were generated by substituting varying lengths of the carboxyl-terminus of duck ...
Jaesung Jung +8 more
doaj +1 more source