Results 11 to 20 of about 1,062,480 (303)

Pharmacological Inhibition of Protein Kinase C Reduces West Nile Virus Replication [PDF]

Viruses, 2018
Flaviviruses are relevant animal and human pathogens that include West Nile virus (WNV), Japanese encephalitis virus, dengue virus, or Zika virus, among others. Currently, no licensed therapy is available to fight flaviviral infections. Protein kinases C
Ana B. Blázquez, Ángela Vázquez-Calvo, Miguel A. Martín-Acebes, Juan-Carlos Saiz   +3 more
doaj   +4 more sources

RSAD2 suppresses viral replication by interacting with the Senecavirus A 2 C protein

Veterinary Research
Senecavirus A (SVA), an emerging virus that causes blisters on the nose and hooves, reduces the production performance of pigs. RSAD2 is a radical S-adenosylmethionine (SAM) enzyme, and its expression can suppress various viruses due to its broad ...
Lei Hou, Zhi Wu, Penghui Zeng, Xiaoyu Yang, Yongyan Shi, Jinshuo Guo, Jianwei Zhou, Jiangwei Song, Jue Liu   +8 more
doaj   +3 more sources

Autophagy proteins promote hepatitis C virus replication [PDF]

Autophagy, 2009
Autophagy is a fundamental process for anti-viral defense. Not surprisingly, viruses have developed strategies to subvert or use autophagy for their own benefit. In cell culture, autophagy proteins are proviral factors that favor initiation of hepatitis C virus (HCV) infection. Autophagy proteins are required for translation of incoming viral RNA.
Dreux, Marlène, Chisari, Francis
openaire   +3 more sources

Differential Binding of Replication Proteins across the Human c-myc Replicator [PDF]

Molecular and Cellular Biology, 2006
The binding of the prereplication complex proteins Orc1, Orc2, Mcm3, Mcm7, and Cdc6 and the novel DNA unwinding element (DUE) binding protein DUE-B to the endogenous human c-myc replicator was studied by chromatin immunoprecipitation. In G(1)-arrested HeLa cells, Mcm3, Mcm7, and DUE-B were prominent near the DUE, while Orc1 and Orc2 were least abundant
Maloy, Ghosh, Michael, Kemp, Guoqi, Liu, Marion, Ritzi, Aloys, Schepers, Michael, Leffak   +5 more
openaire   +2 more sources

ISG56 and IFITM1 Proteins Inhibit Hepatitis C Virus Replication [PDF]

Journal of Virology, 2011
ABSTRACT Hepatitis C virus (HCV) often leads to persistent infection. Interferon (IFN) and IFN-stimulated genes (ISGs) are amplified during HCV infection but fail to eliminate virus from the liver in a large number of infected patients. We have observed previously that HCV infection induces IFN-β production in immortalized human hepatocytes ...
Amit, Raychoudhuri, Shubham, Shrivastava, Robert, Steele, Hangeun, Kim, Ranjit, Ray, Ratna B, Ray   +5 more
openaire   +2 more sources

Hepatitis C virus-induced prion protein expression facilitates hepatitis C virus replication [PDF]

Virologica Sinica, 2017
Hepatitis C virus (HCV) infects approximately 180 million people worldwide. Significant progress has been made since the establishment of in vitro HCV infection models in cells. However, the replication of HCV is complex and not completely understood. Here, we found that the expression of host prion protein (PrP) was induced in an HCV replication cell ...
Huixia Zhang, Shanshan Gao, Rongjuan Pei, Xinwen Chen, Chaoyang Li   +4 more
openaire   +2 more sources

Effect of Phosphorylation of CM2 Protein on Influenza C Virus Replication [PDF]

Journal of Virology, 2017
ABSTRACT CM2 is the second membrane protein of the influenza C virus and has been demonstrated to play a role in the uncoating and genome packaging processes in influenza C virus replication. Although the effects of N-linked glycosylation, disulfide-linked oligomerization, and palmitoylation of CM2 on virus replication have been analyzed, the
Takanari, Goto, Yoshitaka, Shimotai, Yoko, Matsuzaki, Yasushi, Muraki, Ri, Sho, Kanetsu, Sugawara, Seiji, Hongo   +6 more
openaire   +2 more sources

Subunit Interaction Differences Between the Replication Factor C Complexes in Arabidopsis and Rice

Frontiers in Plant Science, 2018
Replication factor C (RFC) is a multisubunit complex that opens the sliding clamp and loads it onto the DNA chain in an ATP-dependent manner and is thus critical for high-speed DNA synthesis.
Yueyue Chen, Jie Qian, Li You, Xiufeng Zhang, Jinxia Jiao, Yang Liu, Jie Zhao   +6 more
doaj   +1 more source

AMPK inhibitor, compound C, inhibits coronavirus replication in vitro.

PLoS ONE, 2023
The coronavirus disease (COVID-19) pandemic has resulted in more than six million deaths by October 2022. Vaccines and antivirals for severe acute respiratory syndrome coronavirus 2 are now available; however, more effective antiviral drugs are required ...
Minsu Jang, Rackhyun Park, Ayane Yamamoto, Yea-In Park, Yeonjeong Park, Siyun Lee, Junsoo Park   +6 more
doaj   +1 more source

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence [PDF]

, 2016
AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression.
Astrologo, Letizia, Biroccio, Annamaria, Burla, Romina, Carcuro, Mariateresa, Crescenzi, Marco, Cundari, Enrico, D'Apice, Maria Rosaria, Fratini, Federica, Gatti, Maurizio, LA TORRE, Mattia, Lattanzi, Giovanna, Raffa, GRAZIA DANIELA, Raimondo, Domenico, Saggio, Isabella, Spitalieri, Paola   +14 more
core   +6 more sources