Results 31 to 40 of about 1,062,480 (303)
A novel Rad24 checkpoint protein complex closely related to replication factor C [PDF]
Current Biology, 2000 Rad24 functions in the DNA damage checkpoint pathway of Saccharomyces cerevisiae. Here, analysis of Rad24 in whole cell extracts demonstrated that its mass was considerably greater than its predicted molecular weight, suggesting that Rad24 is a component of a protein complex. The Rad24 complex was purified to homogeneity.
Green, C +3 more
openaire +4 more sources
Viruses, 2022 During viral evolution and adaptation, many viruses have utilized host cellular factors and machinery as their partners. HBx, as a multifunctional viral protein encoded by the hepatitis B virus (HBV), promotes HBV replication and greatly contributes to ...
Ah Ram Lee +3 more
doaj +1 more source
Role of the CM2 Protein in the Influenza C Virus Replication Cycle [PDF]
Journal of Virology, 2011 ABSTRACT CM2 is the second membrane protein of influenza C virus. Although its biochemical characteristics, coding strategy, and properties as an ion channel have been extensively studied, the role(s) of CM2 in the virus replication cycle remains to be clarified. In order to elucidate this role, in the present study we generated CM2-deficient
Takatoshi, Furukawa +8 more
openaire +2 more sources
Treatment with PTEN-Long protein inhibits hepatitis C virus replication
Virology, 2017 Hepatitis C virus (HCV) infection is a confirmed risk factor for hepatocellular carcinoma (HCC). Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) possesses tumor suppression function that is frequently defective in HCC tumors. PTEN-Long, a translation isoform of PTEN, functions in a cell non-autonomous manner.
Qi, Wu, Zhubing, Li, Qiang, Liu
openaire +2 more sources
Inhibition of the HCV core protein on the immune response to HBV surface antigen and on HBV gene expression and replication in vivo. [PDF]
PLoS ONE, 2012 The hepatitis C virus (HCV) core protein is a multifunctional protein that can interfere with the induction of an immune response. It has been reported that the HCV core protein inhibits HBV replication in vitro.
Wenbo Zhu +8 more
doaj +1 more source
Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins. [PDF]
, 2010 The hnRNP C heterotetramer [(C1(3))C2] binds RNA polymerase II transcripts in the nucleus, along with other proteins of the core hnRNP complex, and plays an important role in mRNA biogenesis and transport.
Brunner, Jo Ellen +3 more
core +1 more source
Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]
, 2017 Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K +6 more
core +2 more sources
Molecular Systems Biology, 2010 The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect viral replication. However, inhibition of the sterol pathway with statin drugs has not yielded
Christopher M Owens +7 more
doaj +1 more source
Viruses, 2020 The morphogenesis of Hepatitis B Virus (HBV) viral particles is nucleated by the oligomerization of HBc protein molecules, resulting in the formation of an icosahedral capsid shell containing the replication-competent nucleoprotein complex made of the ...
Hugues de Rocquigny +5 more
doaj +1 more source
Elimination of hepatitis C virus from hepatocytes by a selective activation of therapeutic molecules. [PDF]
PLoS ONE, 2011 To eliminate hepatitis C virus (HCV) from infected hepatocytes, we generated two therapeutic molecules specifically activated in cells infected with HCV.
Xiaoyu Wen +10 more
doaj +1 more source