Results 41 to 50 of about 1,062,480 (303)

Modelling the structure of full-length Epstein-Barr virus nuclear antigen 1 [PDF]

, 2014
Epstein-Barr virus (EBV) is a clinically important human virus associated with several cancers and is the etiologic agent of infectious mononucleosis. The viral nuclear antigen-1 (EBNA1) is central to the replication and propagation of the viral genome
Gatherer, Derek, Hussain, Mushtaq, Wilson, Joanna Beatrice   +2 more
core   +1 more source

Cleavage of Dicer protein by I7 protease during vaccinia virus infection.

PLoS ONE, 2015
Dicer is the key component in the miRNA pathway. Degradation of Dicer protein is facilitated during vaccinia virus (VV) infection. A C-terminal cleaved product of Dicer protein was detected in the presence of MG132 during VV infection.
Jhih-Si Chen, Hui-Chun Li, Shu-I Lin, Chee-Hing Yang, Wan-Yu Chien, Ciao-Ling Syu, Shih-Yen Lo   +6 more
doaj   +1 more source

Hepatitis C Viral Replication Complex

Viruses, 2021
The life cycle of the hepatitis C virus (HCV) can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release.
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
doaj   +1 more source

Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response [PDF]

, 2017
Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular ...
Cesarec, Mia, Da Silva Filipe, Ana, Licastro, Danilo, Marcello, Alessandro, McLauchlan, John, Çevik, Recep Emrah   +5 more
core   +1 more source

Human astrovirus C-terminal nsP1a protein is involved in RNA replication

Virology, 2005
Human astrovirus nonstructural C-terminal nsP1a protein, which contains a hypervariable region (HVR) and colocalizes with the endoplasmic reticulum and viral RNA, has been suggested to be involved in the RNA replication process. Four viruses differing only in their C-terminal nsP1a protein, corresponding to HVR-derived genotypes IV, V, VI, and XII ...
Guix, Susana, Caballero, Santiago, Bosch, Albert, Pintó, Rosa M.   +3 more
openaire   +2 more sources

The selective autophagic degradation of avian metapneumovirus subgroup C M2-2 protein via SQSTM1 suppresses viral replication

Autophagy Reports
Avian metapneumovirus subgroup C (aMPV/C) is an emerging pathogen that causes acute respiratory infection in chickens and turkeys. Sequestosome 1 (SQSTM1), a selective autophagy receptor, regulates cellular activity or viral replication by recognizing ...
Lei Hou, Jinshuo Guo, Jianwei Zhou, Jue Liu   +3 more
doaj   +1 more source

SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation.

PLoS ONE, 2019
Hepatitis C virus (HCV) replication involves many viral and host factors. Host factor SPRY domain- and SOCS box-containing protein 2(SPSB2) belongs to SPSB family, and it recruits target proteins by the SPRY domain and forms E3 ubiquitin ligase complexes
Mingzhen Wang, Yu Wang, Yuehong Liu, Hailong Wang, Xiu Xin, Jiadai Li, Yao Hao, Lingling Han, Fang Yu, Congyi Zheng, Chao Shen   +10 more
doaj   +1 more source

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]

, 2013
The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem, A Devaraj, AA Malygin, AD Petropoulos, AY Keel, Breanna S Vollmar, C Chen, CM Spahn, CS Fraser, CS Fraser, D Boehringer, D Hartz, D Sousa, Dan Shi, DD Ian'shina, DV Sizova, EF Pettersen, F Odreman-Macchioli, F Peske, F Robert, GA Otto, GJ Kleywegt, H Ji, IB Lomakin, IM Terenin, J Bukh, J Rabl, J Wower, JA Mindell, JE Wilson, Jeffrey S Kieft, JH Kim, JM Fringer, JR Lytle, JR Lytle, JS Kieft, JS Kieft, K Tsukiyama-Kohara, KE Berry, KI Kalliampakou, LA Passmore, M Honda, M Ohi, M Selmer, M Stoneley, M van Heel, ME Filbin, Megan E Filbin, MG Acker, MM Yusupov, N Grigorieff, N Locker, O Galkin, P Antúnez de Mayolo, P Simmonds, PJ Lukavsky, PJ Lukavsky, RE Monro, RJ Jackson, S Fukushi, S Uemura, SM Dibrov, T Döring, Tamir Gonen, TV Pestova, TV Pestova, U Geigenmüller, VG Kolupaeva, Y Yu   +68 more
core   +1 more source

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.

PLoS Biology, 2019
Accurate genome duplication underlies genetic homeostasis. Metazoan Mdm2 binding protein (MTBP) forms a main regulatory platform for origin firing together with Treslin/TICRR and TopBP1 (Topoisomerase II binding protein 1 (TopBP1)-interacting replication
Kerstin Köhler, Luis Sanchez-Pulido, Verena Höfer, Anika Marko, Chris P Ponting, Ambrosius P Snijders, Regina Feederle, Aloys Schepers, Dominik Boos   +8 more
doaj   +1 more source

Interactome Profiling of N-Terminus-Truncated NS1 Protein of Influenza A Virus Reveals Role of 14-3-3γ in Virus Replication

Pathogens, 2022
Influenza A virus is transmitted through a respiratory route and has caused several pandemics throughout history. The NS1 protein of influenza A virus, which consists of an N-terminal RNA-binding domain and a C-terminal effector domain, is considered one
Rei-Lin Kuo, Ee-Hong Tam, Chian-Huey Woung, Chu-Mi Hung, Hao-Ping Liu, Helene Minyi Liu, Chih-Ching Wu   +6 more
doaj   +1 more source