Results 61 to 70 of about 1,062,480 (303)

Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]

, 2012
Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection.

PLoS Pathogens, 2019
Hepatitis C virus (HCV) is a positive-strand RNA virus replicating in a membranous replication organelle composed primarily of double-membrane vesicles (DMVs) having morphological resemblance to autophagosomes.
Jae Seung Lee, Keisuke Tabata, Woan-Ing Twu, Md Shafiqur Rahman, Hee Sun Kim, Jin Bae Yu, Min Hyeok Jee, Ralf Bartenschlager, Sung Key Jang   +8 more
doaj   +1 more source

Mutual antagonism between circadian protein period 2 and hepatitis C virus replication in hepatocytes. [PDF]

PLoS ONE, 2013
BackgroundHepatitis C virus (HCV) infects approximately 3% of the world population and is the leading cause of liver disease, impacting hepatocyte metabolism, depending on virus genotype.
Giorgia Benegiamo, Gianluigi Mazzoccoli, Francesco Cappello, Francesca Rappa, Nunzia Scibetta, Jude Oben, Azzura Greco, Roger Williams, Angelo Andriulli, Manlio Vinciguerra, Valerio Pazienza   +10 more
doaj   +1 more source

Phosphorylation of serine 225 in hepatitis C virus NS5A regulates protein-protein interactions. [PDF]

, 2017
Hepatitis C virus (HCV) non-structural protein 5A (NS5A) is a phosphoprotein that plays key, yet poorly defined, roles in both virus genome replication and virion assembly/release.
Amako, Andreas Pichlmair, Anna Gebhardt, Berger, Chong, Christopher Bartlett, Cochrane, Cordek, Cox, Cox, De Marco, Ester, Evans, Eyre, Feuerstein, Gao, Germain, Gullberg, Gupta, Habjan, Hamamoto, Hsu, Lambacher, Lambert, Lee, Lemay, Lim, Lohmann, Love, Macdonald, Mark Harris, Masaki, Masumi, Michael S. Diamond, Miyaji-Yamaguchi, Nanda, Neuvonen, Niluka Goonawardane, Okuwaki, Paul, Pawlotsky, Pichlmair, Rehtanz, Reiss, Reiss, Romero-Brey, Ross-Thriepland, Ross-Thriepland, Schindelin, Söderberg, Takeuchi, Tellinghuisen, Tellinghuisen, Tellinghuisen, Toth, Tu, Wang, Wang, Webster, Wyles, Xu, York, Zech   +62 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Interferon-Induced Effector Proteins and Hepatitis C Virus Replication

, 2008
Hepatitis C virus (HCV) is a small, enveloped RNA virus that is often capable of establishing a persistent infection, which may lead to chronic liver disease, cirrhosis, hepatocellular carcinoma, and eventually death. For more than 20 years, hepatitis C patients have been treated with interferon-alpha (IFN-α).
Frese, Michael, Dazert, Eva
openaire   +1 more source

Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models. [PDF]

, 2017
Metastasis is a major cause of mortality for cancer patients and remains as the greatest challenge in cancer therapy. Driven by multiple factors, metastasis may not be controlled by the inhibition of single target.
DeVere White, Ralph W, Duan, Zhijian, Ho, Pui Yan, Jian, Chao, Lam, Kit S, Lara, Primo N, Qiu, Jing-Xin, Tu, Mei-Juan, Wun, Theodore, Yu, Ai-Ming, Yu, Ai-Xi, Zhang, Qianyu   +11 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A [PDF]

Hepatology, 2011
The interferon-stimulated gene, viperin, has been shown to have antiviral activity against hepatitis C virus (HCV) in the context of the HCV replicon, although the molecular mechanisms responsible are not well understood.
Helbig, K., Eyre, N., Yip, L., Narayana, S., Li, K., Fiches, G., McCartney, E., Jangra, R., Lemon, S., Beard, M.   +9 more
openaire   +3 more sources