Results 81 to 90 of about 768,011 (297)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Dark Side of Clarity: Its Effect on Knowledge Production and Decision-Making [PDF]
Salus Journal, 2017 Law enforcement decision-makers rely on intelligence analysts to produce intelligence products that are clear. Yet, intelligence analysts live in a world characterised by ambiguity and information overload.
Adrian Wolfberg
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Snowflake Generation – between clarity and spiritual paralysis
Etnosfera, 2022 This material discusses the problem of the young generation, which in the international literature is called the “snowflake generation”. Its main characteristic is its high degree of isolation. This is important because it is linked by experts to several
Samira Cîrlig +2 more
doaj
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The pursuit of clarity, precision and unambiguity in drafting retrospective legislation [PDF]
This dissertation suggests that clarity, precision and unambiguity are the essential tools for expressing retrospective intent, which is a pre-requisite for quality and validity of retrospective legislation.
Turatsinze, Elias
core +3 more sources
Dietetics(1) Background: Patient education materials are frequently used by dietitians to support counselling and reinforce key concepts. No studies have examined the quality of dietetic patient education materials for diabetes and common gastrointestinal ...
Kelly Lambert +2 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Nutrients flow from runoff at burned forest site in Lake Tahoe Basin
California Agriculture, 2006 The long-term trend toward decreased water clarity in Lake Tahoe is well documented, and is strongly linked to increased nitrogen and phosphorus loading from surrounding watersheds.
W. Wally Miller +7 more
doaj +1 more source