Results 111 to 120 of about 24,741,062 (310)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Control Theory for a Class of 2D Continuous-Discrete Linear Systems
, 2004 This paper considers a general class of 2D continuous-discrete linear systems of both systems theoretic and applications interest. The focus is on the development of a comprehensive control systems theory for members of this class in a unified manner ...
Owens, D H +4 more
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2014 Here is an ephemeral object just made for a collection like this! Mrs. Bollen's Class was at Cottage Hill Elementary School in Grass Valley, CA. This print-on demand book of 56 pages gives two pages to each pupil's fable, with a colored picture on the ...
Mrs. Bollen's Class
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Biographical record of the Class of Fifty-eight, Yale College.
Imprint varies: New Britain, Conn.
Yale College. Class of 1858.
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
30 year class book : Class of 1906.
, 1936 30 year class book, Class of 1906, Lehigh University. Pottstown, (Pa.) : The Feroe press 1936. 90 p. : ill., port.
core
Predicting Multi-class Customer Profiles Based on Transactions: a Case Study in Food Sales
, 2012 Predicting the class of a customer profile is a key task in marketing, which enables businesses to approach the right customer with the right product at the right time through the right channel to satisfy the customer's evolving needs.
Apeh, E. +14 more
core +1 more source