Results 61 to 70 of about 33,505,955 (241)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Analysis and Design of High-Frequency CC/CV ZVS WPT System Without Any Feedback From Receiver to Transmitter

IEEE Access
This paper proposes a high-frequency wireless power transfer (WPT) system. This system achieves zero-voltage switching (ZVS) and the constant current (CC) and constant voltage (CV) outputs regardless of load variations and coil misalignment. Furthermore,
Ayano Komanaka, Yinchen Xie, Yutaro Komiyama, Wenqi Zhu, Akihiro Konishi, Xiuqin Wei, Kien Nguyen, Hiroo Sekiya   +7 more
doaj   +1 more source

Design of High Efficiency Illumination for LED Lighting

International Journal of Photoenergy, 2013
A high efficiency illumination for LED street lighting is proposed. For energy saving, this paper uses Class-E resonant inverter as main electric circuit to improve efficiency. In addition, single dimming control has the best efficiency, simplest control
Yong-Nong Chang, Hung-Liang Cheng, Chih-Ming Kuo   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Design and Analysis of Three-Phase Three-Level PWM Inverter [PDF]

, 2010
Design of three-phase three level PWM inverter and analysis of the output current harmonics are presented in this paper. The three-level inverter is designed to supply three-phase load and it is controlled by FPGA under several modulation techniques ...
Dahono, Pekik Argo
core  

Class E Inverter Single Capacitor Wireless Power Transmission System Based on Stable Ground

IEEE Access
Single-capacitor coupled wireless energy transmission has been widely noticed due to its advantages of simple coupling mechanism and absence of cross-coupling capacitance.
Xin Geng, Jiapeng Wang, Jixing Wang, Junjie Ma, Chongqin Wang   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The ZVS Class E/F3 Inverter Using Piezoelectric Transformers for Energy Extraction

, 2023
Enhanced class E inverters (EFn or E/Fn) reduce the high peak switch voltage that is prevalent in class E inverters. Additionally, their stability and load regulation capabilities are improved as compared to class E inverters.
Abdul Rauf Bhatti, Ratil H. Ashique, Md. Hasan Maruf, ASM Shihavuddin, Ahmed Al Mansur, M. Saad Bin Arif   +5 more
core   +1 more source

Modeling and Control of DC to High-Frequency AC Voltage Conversion for Photovoltaic Systems Under Variable Irradiation, Temperature and Load Conditions

Electrica
: This study introduces a model that adjusts the DC voltage output from PV panels through a Cuk Converter while a Class-E inverter produces a high-frequency AC voltage.
Fatih Issi, Mustafa Karhan
doaj   +1 more source