Results 131 to 140 of about 20,214,462 (360)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Dynamics of social class contempt in contemporary British television comedy [PDF]

open access: yes, 2010
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 Taylor & Francis.British television comedy has often ridiculed the complexities and characteristics of social class structures and ...
Lockyer, S, Sharon Lockyer
core   +1 more source

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

open access: yesJournal of Experimental Medicine, 2002
To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues.
L. Bonifaz   +5 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Compact star models in class I spacetime

open access: yesEuropean Physical Journal C: Particles and Fields, 2019
In the present article, we have presented completely new exact, finite and regular class I solutions of Einstein’s field equations i.e. the solutions satisfy the Karmarkar condition. For this purpose needfully we have introduced a completely new suitable
Nayan Sarkar   +3 more
doaj   +1 more source

The Effects of Class Size and Composition on Student Achievement: New Evidence from Natural Population Variation [PDF]

open access: yes
I use natural population variation to identify the effects of class size and composition on student achievement. I isolate the credibly random component of population variation in each grade and school district and use this component to generate ...
Caroline M. Hoxby
core  

Trå oss ikke for nær! Møter mellom «high class» og allmuen i Romsdalen 1860–1926. [PDF]

open access: yes, 2014
Summary The following essay will consider the cultural encounter between representatives of the upper class from foreign countries, mainly British citizens, and the local lower class people in the valley of Romsdalen on the western coast of Norway ...
Langseth, Bjarne
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Mapping the Landscape of Host-Pathogen Coevolution: HLA Class I Binding and Its Relationship with Evolutionary Conservation in Human and Viral Proteins

open access: yes, 2011
The high diversity of HLA binding preferences has been driven by the sequence diversity of short segments of relevant pathogenic proteins presented by HLA molecules to the immune system.
Jojic, N.   +9 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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