Results 241 to 250 of about 20,214,462 (360)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Systematic Evaluation of Peptidomimetic Modifications in a Major Histocompatibility Complex Class I Model Epitope: A Framework for Immunogenic Antigen Design. [PDF]

ACS Chem Biol
Newkirk SE, Kelly JJ, Hourn N, Bhandari S, Spencer N, Pires MM.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

['Lips and incisors position in normal class I occlusion', 'Lips and incisors position in normal class I occlusion']

Al-Rafidain Dental Journal, 2001
Fadhil y. jasim, Neam F. Y. AGHA
doaj   +1 more source

HLA-Knockout: Enabling Allele-Specific Knockout of HLA Class I Genes for Immunogenic Engineering. [PDF]

HLA
Mattivi C, Wang S, Ji L, Xiao Q, Cao J.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

HLA class-I genotyping to personalize Bacille Calmette-Guerin immunotherapy in bladder cancer. [PDF]

Oncoimmunology
Ruiz-Lorente I, Gimeno L, López-Abad A, Cubillana PL, Aparicio TF, Egea LJA, Avilés JM, Iñiguez GD, Martínez-Valls PLG, Server G, Ferri B, Campillo JA, Galindo F, Martínez-Sánchez MV, Minguela A.   +14 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Mapping HLA class I and II allele associations with hepatitis C related liver disease progression in an Egyptian cohort. [PDF]

Discov Oncol
M Lotfy M, Ebrahim NAA, El-Kassas M, Omar Abdel-Aziz A, Abdelhamid Omran D, Abdelfatah D, Barakat AB, Salah El-Din Youssef A, Nassar A, K Soliman H, N Zekri AR.   +10 more
europepmc   +1 more source

The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex

Journal of Virology, 2003
B. Bosch, R. van der Zee, C. D. de Haan, P. Rottier   +3 more
semanticscholar   +1 more source