Results 281 to 290 of about 20,214,462 (360)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Prognostic impact of HLA class I immunohistochemistry staining intensity with regard to the risk of recurrence of adenoid cystic carcinoma. [PDF]

Mol Clin Oncol
Zupancic M, Birgersson M, Friesland S, Dalianis T, Näsman A.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease. [PDF]

Alzheimers Res Ther
Lu W, Kawatani K, Ren Y, Nambara T, Jia L, Jeevaratnam S, Lee E, Martinez PR, Izhar T, Wang N, Raulin AC, Wszolek ZK, Bu G, Kanekiyo T, Li Y.   +14 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Correction: A subset of neutrophil phagosomes is characterised by pulses of Class I PI3K activity. [PDF]

Dis Model Mech
Muir CF, Reyes-Aldasoro CC, Prajsnar TK, Michno BJ, Cholewa-Waclaw J, Ho YX, Bernut A, Loynes CA, Elworthy S, Bowden KA, Cadby AJ, Prince LR, King JS, Ellett F, Condliffe AM, Renshaw SA.   +15 more
europepmc   +1 more source

Clinical evaluation of different bi-layer biomimetic strategies of composite resin in large class I cavities: an 18-month randomized clinical trial. [PDF]

BMC Oral Health
Mohammed MAEG, Hassan MA, Morsy KES.
europepmc   +1 more source

Structural evolution of polymorphic class I HLA alleles, designating HLA-C with uncertain assemblies. [PDF]

Comput Struct Biotechnol J
Padariya M, Marek-Trzonkowska N, Kalathiya U.   +2 more
europepmc   +1 more source

Integrative Neoepitope Discovery in Glioblastoma via HLA Class I Profiling and AlphaFold2-Multimer. [PDF]

Biomedicines
Francés R, Bonifacio-Mundaca J, Casafont Í, Desterke C, Mata-Garrido J.   +4 more
europepmc   +1 more source

Biocatalytic Conversion of Furans into Pyrrolinones Using a Class I Unspecific Peroxygenase. [PDF]

ACS Catal
Melling B, Cornish KAS, Cartwright J, Mulholland NP, Unsworth WP, Grogan G.   +5 more
europepmc   +1 more source