Results 221 to 230 of about 38,654,738 (261)

Targeting B‐Cell‐Activating Factor and Its Receptor in Immune Thrombocytopenia and Warm Autoimmune Hemolytic Anemia

American Journal of Hematology, Volume 101, Issue 11, Page 2836-2852, November 2026.
ABSTRACT Current treatments for immune thrombocytopenia (ITP) and warm autoimmune hemolytic anemia (wAIHA), rare autoimmune diseases in which autoreactive B cells play a major role, can lead to high response rates; however, for many patients these responses are not durable or maintained after treatment discontinuation.
Matthieu Mahévas, Nichola Cooper, Vickie McDonald, Karina Yazdanbakhsh, Wilma Barcellini   +4 more
wiley   +1 more source

The CREM-IL-15 axis: decoding the persistence-exhaustion paradox in NK cell immunotherapy. [PDF]

Cancer Immunol Immunother
El-Sehrawy AAMA, Al-Khreisat MJ, Patel JR, Kibriyeva M, Gulnoza L, Qosimov K, Abdul LM, Tailor NK.   +7 more
europepmc   +1 more source

Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Marianna Maddaluno, Laura Cinque, Viviana Cetrangolo, Chiara De Leonibus   +3 more
wiley   +1 more source

Phosphatidylinositol 4-kinase as a target of pathogens-friend or foe? [PDF]

FEBS Lett
Mendes AC, Azevedo GM, Barcellos AP, Bahia D.   +3 more
europepmc   +1 more source

Myo1g Mediates NKR‐P1C Expression in Primary Mouse NK Cells and Participates in Cytotoxicity

Immunology, Volume 179, Issue 3, Page 516-524, November 2026.
In this study we analysed the participation of Myosin 1g in the development and functions of murine natural killer (NK) cells; we found that Myosin 1g is expressed in murine‐activated primary NK cells from the spleen. Additionally, in the absence of Myosin 1g, correlates with a reduced expression of NKR‐P1C but not of CD49b or NKp46.
Héctor Romero‐Ramírez, Vania Aminta Zuleica López‐Esparza, Mariana Flores‐Castelán, Leopoldo Santos‐Argumedo   +3 more
wiley   +1 more source

The <i>E. coli</i> High-Pathogenicity Island Downregulates <i>PI3K</i>/<i>Akt</i>/<i>mTOR</i> Expression and Induces Autophagy in the Mouse Intestine. [PDF]

Cells
Li W, Zhang B, Zhao W, Wang H, Zhou M, Li Y, Ma J, Chu L, Ruan X, Xiao P, Gao H.   +10 more
europepmc   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, Volume 101, Issue 5, Page 2265-2278, October 2026.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Integrated Phytochemical, Immunological, and Network Pharmacology Investigation of Anti‐Inflammatory Lignans From Zanthoxylum armatum Fruits

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Bioassay‐guided fractionation of Zanthoxylum armatum fruits identifies three bioactive lignans—sesamin, fargesin, and eudesmin. The identified lignans attenuate CpG‐induced dendritic‐cell activation by reducing IL‐12 expression and CD80. Network pharmacology and molecular docking suggest involvement of multiple inflammatory signalling pathways ...
Ningthoujam Indrajit Singh, Salam Pradeep Singh, Chayan Mukherjee, Chingakham Brajakishor Singh   +3 more
wiley   +1 more source

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation [PDF]

Journal of Cell Biology, 2001
Phagosomes acquire their microbicidal properties by fusion with lysosomes. Products of phosphatidylinositol 3-kinase (PI 3-kinase) are required for phagosome formation, but their role in maturation is unknown. Using chimeric fluorescent proteins encoding tandem FYVE domains, we found that phosphatidylinositol 3-phosphate (PI[3]P) accumulates greatly ...
Jonathan M Backer, Sergio Grinstein, Lewis C. Cantley   +2 more
exaly   +3 more sources