Results 241 to 250 of about 38,654,738 (261)

[Effects of class I( phosphatidylinositol-3-kinases inhibitor on gastric cancer cell xenografts in nude mice].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2016
To investigate the effect of recombinant adenovirus (phosphatidylinositol-3-kinases(PI3K)(I()-RNAi-AD which blocks the class I( PI3K signaling pathway on gastric carcinoma cells xenografts in nude mice.Subcutaneous tumor models of nude mice were established with SGC7901 cells and randomly divided into PI3K(I()-RNAi-AD group, NC-RNAi-GFP-AD group and ...
Ru-Lu, Liu, Kui, Zhao, Jia-Lei, Sun, Li-Yan, Yu, Bao-Song, Zhu, Xiao-Dong, Yang, Chun-Gen, Xing   +6 more
openaire   +1 more source

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

Journal of Medicinal Chemistry, 2011
The discovery of 2 (GDC-0980), a class I PI3K and mTOR kinase inhibitor for oncology indications, is described. mTOR inhibition was added to the class I PI3K inhibitor 1 (GDC-0941) scaffold primarily through the substitution of the indazole in 1 for a 2-aminopyrimidine.
Daniel P, Sutherlin, Linda, Bao, Megan, Berry, Georgette, Castanedo, Irina, Chuckowree, Jenna, Dotson, Adrian, Folks, Lori, Friedman, Richard, Goldsmith, Janet, Gunzner, Timothy, Heffron, John, Lesnick, Cristina, Lewis, Simon, Mathieu, Jeremy, Murray, Jim, Nonomiya, Jodie, Pang, Niel, Pegg, Wei Wei, Prior, Lionel, Rouge, Laurent, Salphati, Deepak, Sampath, Qingping, Tian, Vickie, Tsui, Nan Chi, Wan, Shumei, Wang, Binqing, Wei, Christian, Wiesmann, Ping, Wu, Bing-Yan, Zhu, Alan, Olivero   +30 more
openaire   +2 more sources

Faculty Opinions recommendation of Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2001
  +4 more sources

The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells

2010
Background. Bacterial flagellin triggers inflammation in mammalian cells via Toll-like receptor (TLR) 5. Release of the chemokine IL-8 in response to flagellin involves NF-κB, p38 MAP kinase, and phosphatidylinositol 3-kinase (PI3K). However, PI3K has been reported to be either pro- or anti-inflammatory in different model systems.
openaire   +1 more source

INHIBITION OF CLASS I PHOSPHATIDYLINOSITOL 3-KINASES (PI3KS) ISOFORMS IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL): WHICH IS THE BEST THERAPEUTIC STRATEGY?

2014
Background: Class I phosphatidylinositol 3-kinases (PI3Ks) are heterodimeric lipid kinases consisting of a regulatory subunit and one of four catalytic subunits (p110α, p110β, p110γ or p110δ). p110γ/p110δ PI3Ks are highly enriched in leukocytes. In general, PI3Ks regulate a variety of cellular processes including cell proliferation, survival and ...
LONETTI, ANNALISA, CAPPELLINI, ALESSANDRA, A. Spartà, D. Bressanin, BUONTEMPO, FRANCESCA, F. Chiarini, C. Evangelisti, E. Orsini, A. Martelli   +8 more
openaire   +1 more source

The expression level of class III phosphatidylinositol-3 kinase controls the degree of compensatory nephron hypertrophy

American Journal of Physiology - Renal Physiology, 2020
Shu-De Li, Jian-Kang Chen, Jinxian Xu
exaly  

Class IA Phosphatidylinositol 3-Kinase Isoform p110α Mediates Vascular Remodeling

Arteriosclerosis, Thrombosis, and Vascular Biology, 2015
Stephan Rosenkranz, Stephan Baldus, Anja Sterner-Kock   +2 more
exaly  

The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy

Journal of Cell Biology, 2010
Zhenyu Yue, Jennifer L Guerriero, Ji-An Pan   +2 more
exaly  

Class IA Phosphatidylinositol 3-Kinase Signaling in Non-small Cell Lung Cancer

Journal of Thoracic Oncology, 2009
Rick Pearson, Benjamin J Solomon
exaly  

The Role Of Class I Phosphatidylinositol-3-Kinase In TNF-Alpha-Induced CD38 Expression In Human Airway Smooth Muscle Cells

A69. LIPID-MEDIATED SIGNALING, 2011
Joseph A. Jude, Krishnaswamy G. Tirumurugaan, Reynold A. Panettieri, Timothy F. Walseth, Mathur S. Kannan   +4 more
openaire   +1 more source