Results 201 to 210 of about 1,098,809 (268)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Comparative evaluation of compressive strength of CAD-CAM polyetheretherketone and indirect composite Class II inlays: an in vitro study. [PDF]

Saudi Dent J
Sharma N, Mahajan S, Sharma IK, Verma N, Yadav D, Poonia N.   +5 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Polygenic risk scores and HLA class II variants are biomarkers of corticosteroid response in childhood nephrotic syndrome. [PDF]

Kidney Int
Tu T, Ochoa A, Sood A, Dabrik A, Chryst-Stangl M, Lane B, Wu G, Donovan F, Harper U, Chandrasekharappa S, Esezobor C, Solarin A, Hooper D, Sethna C, Amaral S, Kallash M, Rheault M, Verghese P, Dharnidharka V, Salmon E, Weng P, Srivastava T, Seifert ME, Pruette C, Selewski D, Gibson K, Hunley T, Abeyagunawardena A, Thalgahagoda S, Bagga A, Sinha A, Webb N, Greenbaum L, Gharavi A, Kiryluk K, Kretzler M, Guay-Woodford L, Sanna-Cherchi S, Bierzynska A, Koziell A, Welsh G, Saleem M, Rotimi C, Chambers E, Chan C, CureGN Consortium, PNRC Glomerular Disease Group, CIBMTR/NMDP Consortium, Jackson A, Adeyemo A, Gbadegesin R.   +50 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

mRNA Multipeptide-HLA Class II Immunotherapy for Melanoma. [PDF]

Cells
Georgopoulos AP, James LM, Sanders M.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Clinical performance of alkasite and glass-hybrid restorations compared with resin composite in class II cavities: a randomized clinical trial. [PDF]

Clin Oral Investig
Işıklı K, Koc Vural U, Yalcin Cakir F.   +2 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Temporomandibular Joint Changes Assessed by CBCT or MRI Following Functional Appliance Therapy in Skeletal Class II Patients: A Systematic Review. [PDF]

Children (Basel)
Lopponi G, Verdecchia A, Sicca N, Benedetti G, Alsafadi A, Cobo T, Spinas E.   +6 more
europepmc   +1 more source