Results 31 to 40 of about 253,527 (306)

STATE INTERVENTIONISM IN THE LATE CLASSIC MAYA PALENQUE POLITY: HOUSEHOLD AND COMMUNITY ARCHAEOLOGY AT EL LACANDON [PDF]

open access: yes, 2013
Archaeological materials from seven excavated households (three commoner, three elite and a super-elite) from El Lacandón, a rural settlement of the Ancient Maya Palenque polity in Chiapas, Mexico; are analyzed to examine how households and communities ...
LOPEZ BRAVO, ROBERTO
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

And Paper-Based is Better? Towards Comparability of Classic and Cryptographic Voting Schemes [PDF]

open access: yes, 2021
In today\u27s real-world elections the choice of the voting scheme is often more subject to dogma and tradition than the result of an objective and scientific selection process.
Marc Nemes   +4 more
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Development and Validation of Improved Impedance Functions for Roads with Mixed Traffic Using Taxi GPS Trajectory Data and Simulation

open access: yesJournal of Advanced Transportation, 2020
This paper proposes an improved impedance function for roads with mixed traffic. It is known that only limited studies consider the impact of nonmotorized traffic on travel impedance of a road segment, and a comparison of the impedance considering ...
Fei Zhao   +6 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Family Medicine, The Classic Papers [PDF]

open access: yesEducation for Primary Care, 2016
Family physicians are generalists (mined at the postgraduate level to address the majority of primary care needs of patients of all ages in communities they serve. Throughout the world there is a need for family physicians Co serve its Cornerstones of comprehensive health care systems that provide high-quality, cost-effectivc medical and public health ...
Decker, Dominic, Decker, Joseph
openaire   +2 more sources

A short report on the meteorological observations during the polar voyage of the Graf ZeppelinE1

open access: yesMeteorologische Zeitschrift
This paper is the edited translation of the paper by Ludwig Wiekmann and Pavel Molchanov “Kurzer Bericht über die meteorologische-aerologischen Beobachtungen auf der Polarfahrt des Graf Zeppelin” (A short report on the meteorological observations during ...
Ludwig Weickmann   +3 more
doaj   +1 more source

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