Results 61 to 70 of about 8,745,456 (267)

Quantum Gravity: Motivations and Alternatives [PDF]

open access: yes, 2009
The mutual conceptual incompatibility between General Relativity and Quantum Mechanics / Quantum Field Theory is generally seen as the most essential motivation for the development of a theory of Quantum Gravity.
Hedrich, Reiner
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A logic road from special to general relativity [PDF]

open access: yes, 2012
We present a streamlined axiom system of special relativity in first-order logic. From this axiom system we ``derive'' an axiom system of general relativity in two natural steps.
Andréka, Hajnal   +3 more
core  

On the Status of the Geodesic Principle in Newtonian and Relativistic Physics [PDF]

open access: yes, 2011
A theorem due to Bob Geroch and Pong Soo Jang ["Motion of a Body in General Relativity." Journal of Mathematical Physics 16(1), (1975)] provides a sense in which the geodesic principle has the status of a theorem in General Relativity (GR).
Weatherall, James Owen   +1 more
core   +1 more source

A classical Bousso bound for higher derivative corrections to general relativity

open access: yesJournal of High Energy Physics
Focussing on theories for which the higher derivative terms are considered as small corrections in the Lagrangian to Einstein’s two-derivative theory of general relativity (GR), we prove the classical version of the covariant entropy bound (also known as
Sayantani Bhattacharyya   +2 more
doaj   +1 more source

Wormholes and holography: an introduction

open access: yesEuropean Physical Journal C: Particles and Fields, 2022
Wormholes are intriguing classical solutions in General Relativity, that have fascinated theoretical physicists for decades. In recent years, especially in Holography, gravitational Wormhole geometries have found a new life in many theoretical ideas ...
Arnab Kundu
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

The Representation of Time and Change in Mechanics [PDF]

open access: yes, 2005
This paper is concerned with the representation of time and change in classical (i.e., non-quantum) physical theories. One of the main goals is to attempt to clarify the nature and scope of the so-called problem of time: a knot of technical and ...
Belot, Gordon
core  

Black Hole Evaporation: A Perspective from Loop Quantum Gravity

open access: yesUniverse, 2020
A personal perspective on the black hole evaporation process is presented using, as guidelines, inputs from: (i) loop quantum gravity, (ii) simplified models where concrete results have been obtained, and, (iii) semi-classical quantum general relativity.
Abhay Ashtekar
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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