Results 41 to 50 of about 2,307 (164)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
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The Phase Space Elementary Cell in Classical and Generalized Statistics
Entropy, 2013 In the past, the phase-space elementary cell of a non-quantized system was set equal to the third power of the Planck constant; in fact, it is not a necessary assumption. We discuss how the phase space volume, the number of states and the elementary-cell
Piero Quarati, Marcello Lissia
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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Czy możemy wykazać istnienie zjawisk całkowicie przypadkowych?
Zagadnienia Filozoficzne w Nauce, 2018 I show how classical and quantum physics approach the problem of randomness and probability. Contrary to popular opinions, neither we can prove that classical mechanics is a deterministic theory, nor that quantum mechanics is a nondeterministic one.
Marek Kuś
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Classical Logic in the Quantum Context
Quantum Reports, 2020 It is generally accepted that quantum mechanics entails a revision of the classical propositional calculus as a consequence of its physical content. However, the universal claim according to which a new quantum logic is indispensable in order to model ...
Andrea Oldofredi
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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Generalized Uncertainty Principle, Classical Mechanics, and General Relativity
Physics Letters B, 2020 The Generalized Uncertainty Principle (GUP) has been directly applied to the motion of (macroscopic) test bodies on a given space-time in order to compute corrections to the classical orbits predicted in Newtonian Mechanics or General Relativity.
Roberto Casadio, Fabio Scardigli
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
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The Formulations of Classical Mechanics with Foucault’s Pendulum
Physics, 2020 Since the pioneering works of Newton (1643–1727), mechanics has been constantly reinventing itself: reformulated in particular by Lagrange (1736–1813) then Hamilton (1805–1865), it now offers powerful conceptual and mathematical tools for the exploration
Nicolas Boulanger, Fabien Buisseret
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