Results 61 to 70 of about 13,470 (289)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

open access: yesAdvanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu   +12 more
wiley   +1 more source

Suppression of Shock X-Ray Emission in Novae from Turbulent Mixing with Cool Gas

open access: yesThe Astrophysical Journal
Shock interaction in classical novae occurs when a fast outflow from the white dwarf ≳1000 km s ^−1 collides with a slower, cooler shell of gas released earlier in the outburst.
Brian D. Metzger   +2 more
doaj   +1 more source

Real‐Time In Vivo Visualization of Tumor‐Associated Macrophage Reprogramming Using a Nitric Oxide‐Activatable NIR‐II Nanoinducer

open access: yesAdvanced Science, EarlyView.
Reprogramming tumor‐associated macrophages is a promising therapeutic strategy for solid tumors. Here, a nitric oxide (NO)‐activatable NIR‐II fluorescence/photoacoustic nanoinducer (I/E@M2pep) that simultaneously facilitates and visualizes the repolarization of TAMs to an M1‐like phenotype is reported, thereby enhancing anti‐tumor efficacy through M1 ...
Qian Chen   +8 more
wiley   +1 more source

Orbital Period Changes of Recurrent Nova U Scorpii Demonstrate That Mejecta = 26 × Maccreted, So U Sco Is Not a Type Ia Supernova Progenitor

open access: yesThe Astrophysical Journal
Recurrent nova U Scorpii (U Sco) is one of the prototypes for a Type Ia supernova progenitor. The logic is that the white dwarf is near the Chandrasekhar mass and gas is accumulating onto its surface at a near-maximal accretion rate, so it will soon ...
Bradley E. Schaefer, Gordon Myers
doaj   +1 more source

The peculiar nova V1309 Sco/Nova Sco 2008: A candidate twin of V838 Mon

open access: yes, 2010
Nova Scorpii 2008 was the target of our Directory Discretionary Time proposal at VLT+UVES in order to study the evolution, origin and abundances of the heavy-element absorption system recently discovered in 80% of classical novae in outburst.
Banerjee   +36 more
core   +1 more source

Highly Efficient and Environmentally Stable Radiative Cooling Fabric: Integrating Photoluminescence and Hierarchical Core–Shell Fibers

open access: yesAdvanced Science, EarlyView.
A scalable radiative cooling fabric engineered with a multi‐layer assembly core–shell structure and integrated photoluminescent materials is reported. The fabric exhibits remarkable environmental stability, including UV resistance, mechanical durability, hydrophobicity, stain resistance, thermal stability, and flame retardancy, demonstrating its ...
Hongtao Liu   +8 more
wiley   +1 more source

Recurrent Nova V2487 Oph Had Superflares in 1941 and 1942 with Radiant Energies of 1042.5±1.6 erg

open access: yesThe Astrophysical Journal
V2487 Ophiuchi (V2487 Oph) is a recurrent nova with classical nova eruptions in 1900 and 1998, and it is also the most extreme known superflare star. These superflares are roughly hour-long flares with amplitudes and optical energies reaching up to 1.10 ...
Bradley E. Schaefer
doaj   +1 more source

Gamma-ray Novae: Rare or Nearby?

open access: yes, 2016
Classical Novae were revealed as a surprise source of gamma-rays in Fermi LAT observations. During the first 8 years since the LAT was launched, 6 novae in total have been detected to > 5 sigma in gamma-rays, in contrast to the 69 discovered optically in
Brown, Anthony M.   +3 more
core   +1 more source

Electric‐Current‐Induced Phase Transformation in Cu6Sn5 Below Its Equilibrium Transition Temperature

open access: yesAdvanced Science, EarlyView.
Electric current induces a monoclinic‐to‐hexagonal phase transformation in Cu6Sn5 at a measured bulk temperature of ∼120°C, below the equilibrium transition temperature. Ex situ synchrotron x‐ray diffraction, TEM, and matched thermal controls show that current stressing promotes the formation of a retained hexagonal η‐phase post‐stress state not ...
Shih‐kang Lin   +3 more
wiley   +1 more source

Ancient Nova Shells of RX Pup Indicate Evolution of Mass Transfer Rate

open access: yesThe Astrophysical Journal Letters
RX Pup is a symbiotic binary that experienced a nova outburst in the 1970s. Here we report a discovery of a ∼1300 yr old nova shell around the system and a possible detection of a ∼7000 yr old nova shell. Together with the nova shell ejected in the 1970s,
Krystian Iłkiewicz   +4 more
doaj   +1 more source

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