Results 51 to 60 of about 6,456 (218)

STATE MANAGEMENT OF FINANCIAL PROVISION OF THE HEALTH CARE SYSTEM IN UKRAINE

Фінансово-кредитна діяльність: проблеми теорії та практики
The purpose of the article is to study the state and results of state management of financial support in the field of health care in Ukraine. The methodological basis of the article is dialectical methods of scientific knowledge: analysis and synthesis,
Myroslava Shalko, Oksana Domina, Ganna Kotsiurubenko, Daryna Melnyk , Nataliia Yevtushenko , Igor Korobko   +5 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Reunderstanding the classical prescription Banxia Xiexin Decoction: new perspectives from a comprehensive review of clinical research and pharmacological studies

Chinese Medicine
Classical prescriptions of Chinese medicine represent the crystallized wisdom of millennia of clinical practice, enduring as cornerstones of therapeutic intervention due to their demonstrated efficacy across generations.
Chang Liu, Pengwei Gao, Xiaoying Liu, Min Kuang, Haoran Xu, Yangming Wu, Wenjun Liu, Shengpeng Wang   +7 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effect of Jingfang Huangjing liquor on psoriasis-like mice [PDF]

Zhongguo niangzao
The therapeutic effect of the traditional Chinese medicine Huangjing liquor on psoriasis-like mice was studied. A psoriasis-like mouse model was constructed with 5% imiquimod (IMQ) cream, the effect of blank control group, model group, methotrexate group,
ZHAO Xiangjun, CUI Junli, LIU Zixi, SU Haixiao, HOU Lin
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source