Results 61 to 70 of about 6,456 (218)

Lion Statuette with Male Figure from the Anatolian Civilizations Museum

Ankara Araştırmaları Dergisi
In 25 BC, Amyntas the king of Galatians bequathed his kingdom to the Roman Empire. Galatia became the new province of the Roman Empire and Ancyra served as the capital.
İbrahim Ethem Koçak
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Булевтерионът на Сердика

Българско е-Списание за Археология, 2021
The article offers a critical overview of the discussion concerning the chronological periods of the bouleuterion in Serdica. The building has been studied several times by different scholars, each proposing their own view on the architectural changes ...
Mario Ivanov
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Attic Black-Glazed Pottery from Olbia Pontica: A Study of the Excavation Area “P-1”

Археологія
This article presents the results of archaeological research on black-glazed pottery from the “Peredmistia 1” area of Olbia Pontica, excavated during the 2018 and 2021 seasons.
I. O. Chechulina , O. H. Kuzmishchev , J. Fornasier   +2 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Rapid production of monoclonal antibodies from single mouse B cells against FMDV

Animal Diseases
Single B-cell antibody generation technology is an advanced method that offers several advantages, including rapid production, high efficiency, and high yield.
Zhengxin Yang, Fangtao Li, Mengjia Zhang, Yan Li, Qizu Zhao, Chunyan Wang, Lu Xu, Yebing Liu, Wentao Li, Yuanyuan Zhu   +9 more
doaj   +1 more source

Structure Elucidation and Immunostimulatory Activity Evaluation of a Galactoglucan from Alpinia officinarum Hance

Foods
Alpinia officinarum Hance has a medicinal history of thousands of years in treating cough, diabetes, and gastrointestinal system diseases, and it is also a medicine food homology (MFH) plant in China.
Zhou Xu, Yanxia Xiong, Pei Hu, Long Chen, Jianhua Wan, Chenggang Huang, Wenjun Liu   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source