Results 31 to 40 of about 21,764 (306)
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Entropy, 2012 We consider non-equilibrium open statistical systems, subject to potentials and to external “heat baths” (hb) at thermal equilibrium at temperature T (either with ab initio dissipation or without it).
Ramon F. Alvarez-Estrada
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A current algebra approach to the equilibrium classical statistical mechanics and its applications
Condensed Matter Physics, 2013 The non-relativistic current algebra approach is analyzed subject to its application to studying the distribution functions of many-particle systems at the temperature equilibrium and their stability properties.
N. Bogolubov, A. Prykarpatsky
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On the foundations of a new approach to statistical mechanics of classical systems
International Journal of Mathematics and Mathematical Sciences, 1980 It has been known for a long time that the fundamental approaches to equilibrium and nonequillbrium statistical mechanics available at present lead to physical and mathematical inconsistencies for dense systems.
S. N. Bagghi
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Probability, Entropy, and Gibbs’ Paradox(es)
Entropy, 2018 Two distinct puzzles, which are both known as Gibbs’ paradox, have interested physicists since they were first identified in the 1870s. They each have significance for the foundations of statistical mechanics and have led to lively discussions with
Robert H. Swendsen
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FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
Condensed Matter Physics, 2018 A simple ansatz for the study of velocity autocorrelation functions in fluids at different timescales is proposed. The ansatz is based on an effective summation of the infinite continued fraction at a reasonable assumption about convergence of relaxation
V.V. Ignatyuk, I.M. Mryglod, T. Bryk
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