Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
ANALISIS PERBANDINGAN KARAKTERISTIK PSIKOMETRI TES KEMAMPUAN DIFERENSIAL (TKD) III ANALOGI VERBAL DENGAN MENGGUNAKAN PENDEKATAN CLASSICAL TEST THEORY (CTT) & ITEM RESPONSE THEORY (IRT) [PDF]
Penelitian ini bertujuan untuk menguji kembali karakteristik psikometri dari TKD III Analogi Verbal. Untuk menguji karakteristik psikometri TKD III Analogi Verbal, peneliti menggunakan dua pendekatan yakni pendekatan item response theory dan classical
Andhini Purnama
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ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou +16 more
wiley +1 more source
MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru +13 more
wiley +1 more source
The study assessed the difference between Classical Test Theory (CTT) and Item Response Theory (IRT) methods of scoring multiple-choice objective test items. The sample comprised of pupils from three purposively selected primary schools in Pankshin Local
Dadughun, Saurayi Isa
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A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source
White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian +8 more
wiley +1 more source
Chinese version of Yoon Critical Thinking Disposition Instrument: validation using classical test theory and Rasch analysis. [PDF]
Au ML, Li YY, Tong LK, Wang SC, Ng WI.
europepmc +1 more source
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro +14 more
wiley +1 more source
Test Items Analysis of Mathematical Problem Solving Ability using a Classical Test Theory Approach [PDF]
This study aims to analyze the item characteristics of the mathematics problem-solving ability test instrument using the Classical Test Theory model.
Ridwan, Muhammad Rais +2 more
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