Results 51 to 60 of about 396,157 (408)
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Architectural classics of the future
Проект БайкалThe article is devoted to the history of classical architectural tradition, which is considered as a development path of the meanings of anthropogenic space from the prehistoric era to the present day and as a basis for further transformation of the so ...
Дмитрий Швидковский +1 more
doaj +1 more source
Detecting desertification in the ancient oases of southern Morocco
Scientific Reports, 2023 Understanding what led to desertification in the long-term is crucial for adaptation to climate change and pressures on resources in North Africa, but existing maps do not accurately show the extent of degraded land or the traditional water systems which
Louise Rayne +7 more
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Social Sciences, 2019 This paper aims to analyse the arguments in favour and against applying Political Correctness policies on campus, especially on the curricula. The arguments in favour that will be studied are the criticism of the canon and the fair representation of ...
Oscar Pérez de la Fuente
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Umanistica Digitale, 2021 This paper describes the preliminary results of an ancient history and computer science collaboration to apply machine learning to the identification of text within images of inscriptions, one of our major sources of evidence for the Roman world.
Charlotte Tupman +2 more
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source