Results 71 to 80 of about 12,837 (265)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Classical Political Philosophy and the Crisis of Modernity – An alternative to the competition State
Nordicum-Mediterraneum, 2017 The conservative Jewish, German and American philosopher Leo Strauss (1899-1973) proposes an interpretation of the causes of the crisis of modernity and argues that the only way in which we can reestablish social stability is to go back to classical ...
Jacob Dahl Rendtorff
doaj
On undying classicism and subverters of foundations
Проект БайкалDirections (styles) in culture have different reserves of strength and different inertia. Among them there is a unique one capable of revival. It is classicism, which is characterized by a timeless understanding of the laws of harmony and beauty based ...
Елена Багина
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Nordicum-Mediterraneum, 2011 Book review of Pia Guldiger's and Jane H. Petersen's Meeting of cultures in the Black Sea region. Between conflict and coexistence (Aarhus: Aarhus University Press, 2008).
Carlo Cantaluppi
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Nordicum-Mediterraneum, 2016 Book review of: Maria Sommer & Dion Sommer, Care, Socialization and Play in Ancient Attica. A Developmental Childhood Archaeological Approach (Aarhus: Aarhus University Press, 2015)
Kristina Egumenovska
doaj
Cancellare i testi antichi o gli antichisti? ‘Cancel Culture’ e censura dei corpi
GriseldaonlineThe essay reconstructs the debate on Cancel Culture and the decolonization of classical studies, analyzing its us origins and its distorted reception in Europe.
Alice Borgna
doaj +1 more source
Les désignations des Grecs d’Asie à l’époque classique, entre ethnicité et jeux politiques
Erga-Logoi, 2018 The designations of the Greeks of Asia in classical literature bear witness to a process which has been highlighted in studies on ethnicity (relational character, dynamism, interaction between exogenous and endogenous appellations), but they also prove ...
Dominique Lenfant
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source