Results 91 to 100 of about 359,341 (361)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Social Sciences, 2019 This paper aims to analyse the arguments in favour and against applying Political Correctness policies on campus, especially on the curricula. The arguments in favour that will be studied are the criticism of the canon and the fair representation of ...
Oscar Pérez de la Fuente
doaj +1 more source
Classical Intentionality [PDF]
Erkenntnis, 2006 In the first part, the paper describes in detail the classical conception of intentionality which was expounded in its most sophisticated form by Edmund Husserl. This conception is today largely eclipsed in the philosophy of mind by the functionalist and by the representationalist account of intentionality, the former adopted by Daniel Dennett and ...
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The ‘Belgrade Circle’ : Pushkin, Lermontov, Gogol and Tolstoy in Serbian interwar comics [PDF]
, 2020 As not everyone knows, the ‘Belgrade Circle’, the collective of comics authors who ushered in the so-called ‘Golden Age of Serbian comics’ (from the 1930s until WW II), had many Russian émigrés among its members. This contribution mainly deals with their
De Dobbeleer, Michel
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Menorah Review (No. 72, Winter/Spring, 2010) [PDF]
, 2010 A Philosopher Rediscovers His Jewish Roots -- An Extraordinary Rabbinic Life -- An Interpretation of Isiah 6.8-10 -- Books in Brief: New and Notable -- Moreshet: From the Classics -- The Noah Affair -- Who Owns and Who is Responsible for a ...
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
, 1960 In common with most readers, excepting the fanatical culture seekers, the concept of a list of "great books, " which every educated man or woman must read, strikes me as dreary and dull.
Downs, Robert B.
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