Results 81 to 90 of about 3,073,916 (262)

Performance Issues in Shape Classification [PDF]

, 2002
Shape comparisons of two groups of objects often have two goals: to create a classifier to separate the groups and to provide information that shows differences between classes. We examine issues that are important for shape analysis in a study comparing schizophrenic patients to normal subjects.
Samson J. Timoner, Pollina Golland, Ron Kikinis, Martha E. Shenton, W. Eric L. Grimson, William M. Wells   +5 more
openaire   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Comparative Analysis of Machine Learning Models for Predicting Innovation Outcomes: An Applied AI Approach

Applied Sciences
Predicting innovation outcomes at the firm level continues to be an important but challenging goal for researchers and practitioners alike. In this study, multiple machine learning models, encompassing both ensemble-based and single-model approaches ...
Marko Martinović, Kristian Dokic, Dalibor Pudić   +2 more
doaj   +1 more source

CLASSIFICATION OF MARKETING PERFORMANCE INDICATOR

, 2020
According to the results of the study conducted, it is proved that the use of an appropriate assessment system of results obtained and effects achieved plays an important role in the management of marketing performance, as in any other management process.
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Well Begun Is Half Done: The Impact of Pre-Processing in MALDI Mass Spectrometry Imaging Analysis Applied to a Case Study of Thyroid Nodules

Stats
The discovery of proteomic biomarkers in cancer research can be effectively performed in situ by exploiting Matrix-Assisted Laser Desorption Ionization (MALDI) Mass Spectrometry Imaging (MSI).
Giulia Capitoli, Kirsten C. J. van Abeelen, Isabella Piga, Vincenzo L’Imperio, Marco S. Nobile, Daniela Besozzi, Stefania Galimberti   +6 more
doaj   +1 more source

Predicting Query Performance via Classification [PDF]

, 2010
We investigate using topic prediction data, as a summary of document content, to compute measures of search result quality. Unlike existing quality measures such as query clarity that require the entire content of the top-ranked results, class-based statistics can be computed efficiently online, because class information is compact enough to precompute
Kevyn Collins-Thompson, Paul N. Bennett
openaire   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source