Results 31 to 40 of about 6,147 (145)
Building an evaluation instrument for OO CASE tool assessment for Unified Modelling Language support [PDF]
, 1999 The Unified Modelling Language (UML) as delivered in September 1997 offers the structure and dynamics of its modelling constructs developed in order to standardise different object oriented (OO) development practices.
Juric, R. +3 more
core +1 more source
Identification of Missing Knowledge in MBSE System Models Using Graph‐Based Machine Learning
Systems Engineering, EarlyView.ABSTRACT The design and development of complex aerospace systems pose significant challenges due to their growing complexity. Iterative design processes, guided by formal specifications, strive to refine initially vague characteristics through multiple stages.
Esma Karagoz +2 more
wiley +1 more source
Mission Aware Cyber‐Physical Security
Systems Engineering, EarlyView.ABSTRACT Perimeter cybersecurity, while essential, has proven insufficient against sophisticated, coordinated, and cyber‐physical attacks. In contrast, mission‐centric cybersecurity emphasizes finding evidence of attack impact on mission success, allowing for targeted resource allocation to mitigate vulnerabilities and protect critical assets.
Georgios Bakirtzis +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez +13 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind +6 more
wiley +1 more source
The FEBS Journal, EarlyView.Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk +8 more
wiley +1 more source
TGFβ enhances platelet–breast‐cancer‐cell interaction and promotes platelet aggregation
The FEBS Journal, EarlyView.TGFβ stimulation promotes EMT in MCF7 cells, increasing their ability to bind, activate, and aggregate PLT. This effect involves the upregulation of adhesion molecules Integrin‐αv and Galectin‐3. Inhibiting Integrin‐αv or Galectin‐3, through Cilengitide and GB1103, reduces PLT adhesion to MCF7 and PLT aggregation, suggesting a mechanism linking TGFβ ...
Margherita Genitoni +7 more
wiley +1 more source
The National Transport Data Framework [PDF]
, 2008 Report by Professor Peter Landshoff (Cambridge University) and Professor John Polak (Imperial College London) on a project for the Department for Transport.
Landshoff, Peter Vincent, Polak, John
core
Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35
The FEBS Journal, EarlyView.Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima +11 more
wiley +1 more source
Panel discussion: Proposals for improving OCL [PDF]
, 2014 During the panel session at the OCL workshop, the OCL community discussed, stimulated by short presentations by OCL experts, potential future extensions and improvements of the OCL.
Brucker, Achim D. +7 more
core +2 more sources