Results 31 to 40 of about 258 (113)

Rethinking Collinearity in Self‐Organizing Maps: Evidence From Geophysical Data Classification

open access: yesJournal of Geophysical Research: Machine Learning and Computation, Volume 3, Issue 2, April 2026.
Abstract This study examines the impact of collinearity on unsupervised machine learning algorithms (UMLAs), specifically Self‐Organizing Maps (SOMs), for detecting lithological boundaries in geophysical data. Using a multi‐scale experimental framework that includes bivariate isotropic clusters, geologically complex Noddy simulations, and real‐world ...
Limin Xu   +2 more
wiley   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 7, Page 1404-1426, April 2026.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez   +13 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, Volume 20, Issue 3, Page 823-837, March 2026.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Towards Enhancing Healthcare Data Privacy: Integrating BioClinicalBERT With Polyalphabetic Cipher for Entity Recognition and Anonymization

open access: yesEngineering Reports, Volume 8, Issue 3, March 2026.
This study presents a dual‐layered anonymization model combining BioClinicalBERT and polyalphabetic cipher to accurately identify and protect sensitive healthcare data. It achieves strong F1 scores while maintaining data utility, enabling privacy‐preserving clinical research compliant with GDPR and HIPAA regulations.
Deblina Mazumder Setu   +3 more
wiley   +1 more source

Maternal and Pediatric Precision in Therapeutic Knowledge Portal (MPRINT‐KP): Landscape Analysis of Pharmacology Research in Maternal and Pediatric Patient Populations

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Pregnant women and children have been underrepresented in clinical studies due to ethical concerns and perceived vulnerabilities. This resulted in a significant gap in knowledge regarding the safety and efficacy of medications for these populations.
Xiaofu Liu   +32 more
wiley   +1 more source

Addressing Complexity in System of Systems With GraphRAG: An AI‐Driven Framework for Dynamic Data Integration

open access: yesSystems Engineering, Volume 29, Issue 2, Page 150-168, March 2026.
ABSTRACT System of Systems (SoS) environments are inherently complex, involving numerous operationally and managerially independent component systems with hidden interdependencies and frequent interactions based on unstructured data. In this paper, we propose using graphical Retrieval‐Augmented Generation (GraphRAG), a tool that combines large language
Yinchien Huang   +2 more
wiley   +1 more source

Identification of Missing Knowledge in MBSE System Models Using Graph‐Based Machine Learning

open access: yesSystems Engineering, Volume 29, Issue 2, Page 133-149, March 2026.
ABSTRACT The design and development of complex aerospace systems pose significant challenges due to their growing complexity. Iterative design processes, guided by formal specifications, strive to refine initially vague characteristics through multiple stages.
Esma Karagoz   +2 more
wiley   +1 more source

Mission Aware Cyber‐Physical Security

open access: yesSystems Engineering, Volume 29, Issue 2, Page 354-367, March 2026.
ABSTRACT Perimeter cybersecurity, while essential, has proven insufficient against sophisticated, coordinated, and cyber‐physical attacks. In contrast, mission‐centric cybersecurity emphasizes finding evidence of attack impact on mission success, allowing for targeted resource allocation to mitigate vulnerabilities and protect critical assets.
Georgios Bakirtzis   +3 more
wiley   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

open access: yesThe FEBS Journal, Volume 293, Issue 6, Page 1681-1707, March 2026.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk   +8 more
wiley   +1 more source

Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35

open access: yesThe FEBS Journal, Volume 293, Issue 5, Page 1386-1399, March 2026.
Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima   +11 more
wiley   +1 more source

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