Results 31 to 40 of about 253 (115)

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, Volume 599, Issue 21, Page 3113-3123, November 2025.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, Volume 19, Issue 11, Page 3409-3426, November 2025.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, Volume 15, Issue 11, Page 1874-1885, November 2025.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids

FEBS Open Bio, Volume 15, Issue 11, Page 1814-1826, November 2025.
Sarcosine oxidase from Bacillus sp. (SoxB) recognizes l‐proline (l‐Pro), d‐proline (d‐Pro), and l‐thioproline (l‐Tpr) as minor substrates. In this study, we measured their absorption spectra, determined the crystal structures of their enzyme complexes, and performed site‐directed mutagenesis of key residues.
Yuqi Zhang, Yoshitaka Nakajima, Masae Kurobe, Tsutomu Nakamura, Tomoki Himiyama, Yoshiaki Nishiya   +5 more
wiley   +1 more source

Hierarchical Superposition Framework Reveals the Complex Effects of Natural Medicine Formulas

Advanced Intelligent Systems, Volume 7, Issue 11, November 2025.
A novel hierarchical superposition pharmacological model incorporates the principle of hierarchical structures from physics to simulate the spatiotemporal dynamics of drug combinations, to elucidate the universal law underlying drug combination effects. By modeling cross‐level causal transmission and attenuation, it advances beyond traditional additive
Weifeng Liang, Dingsi Xiang, Shengli Mi, Jiajun Huang   +3 more
wiley   +1 more source

Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling

British Journal of Pharmacology, Volume 182, Issue 22, Page 5517-5535, November 2025.
Abstract Background and Purpose Hepatocellular carcinoma (HCC), the third leading cause of cancer‐related deaths worldwide, has limited treatment options and high mortality rate. We previously used a bioinformatics approach to identify niclosamide (NIC) as a promising repurposed drug candidate for HCC.
Mingdian Tan, Wei Ye, Yi Liu, Xiaowu Chen, Lakshmi Huttad, Mei‐Sze Chua, Samuel So   +6 more
wiley   +1 more source

Butyrate suppresses mucosal inflammation in inflammatory bowel disease primarily through HDAC3 inhibition in monocytes and macrophages

The FEBS Journal, Volume 292, Issue 22, Page 6134-6157, November 2025.
Butyrate mitigates intestinal inflammation in IBD. It does so primarily by suppressing pro‐inflammatory cytokines and costimulatory molecules in activated monocytes and macrophages, concomitant with enhancing pathogen clearance. In human colonic organoids, butyrate promotes epithelial expression of key genes involved in barrier function and immune ...
Daniela Parada‐Venegas, Marjorie De la Fuente López, Karen Dubois‐Camacho, Glauben Landskron, Tjasso Blokzijl, Héctor Molina, María‐Celeste Casanova, Yingying Cui, Moting Liu, Antonio M. Da Costa De Pina, Daniela Simian, María‐Julieta González, Rinse K. Weersma, Rodrigo Quera, Gerard Dijkstra, Klaas Nico Faber, Marcela A. Hermoso   +16 more
wiley   +1 more source

Enhancing Adverse Event Reporting With Clinical Language Models: Inpatient Falls

Journal of Advanced Nursing, Volume 81, Issue 11, Page 8016-8027, November 2025.
ABSTRACT Aims To develop a method for computationally detecting fall events using clinical language models to complement existing self‐reporting mechanisms. Design Retrospective observational study. Methods Text data were collected from the unstructured nursing notes of three hospitals' electronic health records and the Korean national patient safety ...
Insook Cho, Hyunchul Park, Byeong Sun Park, Dong‐geon Lee   +3 more
wiley   +1 more source

Integrated data model for bridges with 3D geometry and maintenance information

Computer-Aided Civil and Infrastructure Engineering, Volume 40, Issue 27, Page 4994-5009, 14 November 2025.
Abstract The Japanese government has been promoting construction information modeling initiatives, following the example of building information modeling, which has been widely adopted in the construction sector of Western countries. However, progress in preparing and utilizing 3D data for existing structures, which are primarily subject to maintenance
Kenji Nakamura, Yoshinori Tsukada, Toshio Teraguchi, Chikako Kurokawa, Ryuichi Imai   +4 more
wiley   +1 more source

Generating repairs for inconsistent models. [PDF]

Softw Syst Model, 2023
Marchezan L, Kretschmer R, Assunção WKG, Reder A, Egyed A.   +4 more
europepmc   +1 more source