Results 161 to 170 of about 197,388 (314)

Comparison of local large language models for extraction of signs and symptoms data from electronic health records. [PDF]

PLoS One
Spiero I, Rijk MH, Scheeres MA, Rutten FH, Geersing GJ, Platteel TN, Moons KGM, Hooft L, Damen JAA, Venekamp RP, Leeuwenberg AM.   +10 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Combined multiple SVM classifiers based on choquet integral with respect to L- measure

, 2010
[[abstract]]Combining multiple classifiers is a natural way to explore useful information and improve the performances of individual classifiers. Support vector machine (SVM) has an excellent ability to solve the classification problems.
Lin, Wen-Chih ; Huang, Chih-Sheng ; Huang, Wen-Chun
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A Consolidated Framework for the Detection of Alzheimer's Disease Using EEG Signals and Hybrid Models. [PDF]

Biomimetics (Basel)
Prabhakar SK, Won DO.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Strategic Data Re-Uploads: A Pathway to Improved Quantum Classification Data Re-Uploading Strategies for Improved Quantum Classifier Performance. [PDF]

Entropy (Basel)
Aminpour S, Banad YM, Sharif SS.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Foreign Body Response to Neuroimplantation: Machine Learning-Assisted Quantitative Analysis of Astrogliosis. [PDF]

Int J Mol Sci
Melnikova AA, Egorchev AA, Rosin AA, Nurullin LF, Lipachev NS, Vedischeva DS, Derzhavin DV, Perepechenov SS, Sukhodolova EA, Shabernev GV, Titova AA, Kiyamova RG, Kiyasov AP, Chickrin DE, Aganov AV, Samigullin DV, Popova IY, Paveliev M.   +17 more
europepmc   +1 more source